Kv channel interacting proteins are members of a family of voltage-gated potassium (
Kv) channel-interacting
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respon ...
s (KCNIPs, also frequently called "KChIP"), which belong to the
recoverin branch of the
EF-hand
The EF hand is a helix–loop–helix structural domain or ''motif'' found in a large family of calcium-binding proteins.
The EF-hand motif contains a helix–loop–helix topology, much like the spread thumb and forefinger of the human hand, in ...
superfamily.
Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the
N-terminus
The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide, referring to the free amine group (-NH2) located at the end of a polypeptide. Within a peptide, the ami ...
. They are integral subunit components of native K
v4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms.
Members of this family include:
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KCNIP1
Kv channel-interacting protein 1 also known as KChIP1 is a protein that in humans is encoded by the ''KCNIP1'' gene.
Function
This gene encodes a member of the family of voltage-gated potassium ( Kv) channel-interacting proteins (KCNIPs, also ...
, a protein that in humans is encoded by the ''KCNIP1''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
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KCNIP2
Kv channel-interacting protein 2 also known as KChIP2 is a protein that in humans is encoded by the ''KCNIP2'' gene.
Function
This gene encodes a member of the family of voltage-gated potassium ( Kv) channel-interacting proteins (KCNIPs, also ...
, a protein that in humans is encoded by the ''KCNIP2'' gene.
*
KCNIP3
Calsenilin is a protein that in humans is encoded by the ''KCNIP3'' gene.
Function
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the neuronal calcium sensor family of pro ...
, more commonly known as
Calsenilin
Calsenilin is a protein that in humans is encoded by the ''KCNIP3'' gene.
Function
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the neuronal calcium sensor family of pr ...
, a protein that in humans is encoded by the ''KCNIP3'' gene.
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KCNIP4
Kv channel-interacting protein 4 is a protein that in humans is encoded by the ''KCNIP4'' gene.
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch o ...
, a protein that in humans is encoded by the ''KCNIP4'' gene.
References
{{SIA
EF-hand-containing proteins