Keith E. Mostov is an American cell biologist. He received a BA from

University of Chicago The University of Chicago (UChicago, Chicago, or UChi) is a Private university, private research university in Chicago, Illinois, United States. Its main campus is in the Hyde Park, Chicago, Hyde Park neighborhood on Chicago's South Side, Chic ...

in 1976 and during 1976–77 he was a

Rhodes Scholar The Rhodes Scholarship is an international Postgraduate education, postgraduate award for students to study at the University of Oxford in Oxford, United Kingdom. The scholarship is open to people from all backgrounds around the world. Esta ...

New College, Oxford New College is a constituent college of the University of Oxford in the United Kingdom. Founded in 1379 by Bishop William of Wykeham in conjunction with Winchester College as New College's feeder school, New College was one of the first col ...

. Mostov received a

PhD A Doctor of Philosophy (PhD, DPhil; or ) is a terminal degree that usually denotes the highest level of academic achievement in a given discipline and is awarded following a course of graduate study and original research. The name of the deg ...

Biological Science Biology is the scientific study of life and living organisms. It is a broad natural science that encompasses a wide range of fields and unifying principles that explain the structure, function, growth, origin, evolution, and distribution of ...

from the

Rockefeller University The Rockefeller University is a Private university, private Medical research, biomedical Research university, research and graduate-only university in New York City, New York. It focuses primarily on the biological and medical sciences and pro ...

in the laboratory of Nobel laureate

Günter Blobel Günter Blobel (; May 21, 1936 – February 18, 2018) was a Silesian German and American biologist and 1999 Nobel Prize laureate in Physiology for the discovery that proteins have intrinsic signals that govern their transport and localization in ...

in 1983, and an MD from

Weill Cornell Medicine Weill Cornell Medicine (; officially Joan and Sanford I. Weill Medical College of Cornell University), originally Cornell University Medical College, is the medical school of Cornell University, located on the Upper East Side of Manhattan in Ne ...

in 1984. He was a Whitehead Fellow at the

Whitehead Institute Whitehead Institute for Biomedical Research is a non-profit research institute located in Cambridge, Massachusetts, United States that is dedicated to improving human health through basic biomedical research. It was founded as a fiscally indep ...

of MIT from 1984 to 1989. In 1989, Mostov joined the faculty of the University of California, San Francisco, School of Medicine, where he is currently Professor. Mostov and colleagues discovered and sequenced the

Polymeric Immunoglobulin Receptor Polymeric immunoglobulin receptor (pIgR) is a Protein, transmembrane protein that in humans is encoded by the ''PIGR'' gene. It is an Fc receptor which facilitates the transcytosis of the soluble polymeric isoforms of immunoglobulin A and immunogl ...

(pIgR) and proposed the generally accepted model of its pathway and function. Neil E. Simister and Mostov cloned and sequenced the Neonatal Fc Receptor (

FcRn The neonatal fragment crystallizable (Fc) receptor (also FcRn, IgG receptor FcRn large subunit p51, or Brambell receptor) is a protein that in humans is encoded by the ''FCGRT'' gene. It is an IgG Fc receptor which is similar in structure to t ...

). Mostov and colleagues showed how signals in the pIgR direct its polarized trafficking and how polarized

MDCK Madin-Darby canine kidney (MDCK) cells are a model mammalian cell line used in biomedical research. MDCK cells are used for a wide variety of cell biology studies including cell polarity, cell-cell adhesions (termed adherens junctions), collectiv ...

epithelial cells form three-dimensional structures with lumens and tubules. Mostov and colleagues further found how simple rules cause different branching patterns in kidney as compared to other branching tubular organs

Honors and awards

* Rhodes Scholar * Searle Scholar *Charles E. Culpeper Foundation Medical Scholar * Mallinckrodt Foundation Scholar *NIH NIAID MERIT Award * American Society for Cell Biology ASCB Fellow

References

{{DEFAULTSORT:Mostov, Keith E. 1956 births Living people Rockefeller University alumni Weill Cornell Medical College alumni University of Chicago alumni UCSF School of Medicine faculty American cell biologists 20th-century American biologists 21st-century American biologists Scientists from New York City American Rhodes Scholars