Keratin, type I cuticular Ha3-II is a

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...

that in humans is encoded by the ''KRT33B''

gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...

. The protein encoded by this gene is a member of the

keratin Keratin () is one of a family of structural fibrous proteins also known as ''scleroproteins''. It is the key structural material making up Scale (anatomy), scales, hair, Nail (anatomy), nails, feathers, horn (anatomy), horns, claws, Hoof, hoove ...

gene family. It is one of the

type I hair keratin Hair keratin is a type of keratin found in hair and the nails. Function Originating from the embryonic epidermis, the hair follicle evolves into one of the most complex structures in the human body, comprising 7–8 distinct tissue sections. ...

genes which are clustered in a region of

chromosome 17 Chromosome 17 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 17 spans more than 84 million base pairs (the building material of DNA) and represents between 2.5 and 3% of the total DN ...

q21.2 and have the same direction of transcription. As a type I hair keratin, it is an acidic protein which

heterodimerize In biochemistry, a protein dimer is a macromolecular complex or multimer formed by two protein monomers, or single proteins, which are usually non-covalently bound. Many macromolecules, such as proteins or nucleic acids, form dimers. The word ...

s with

type II hair keratin Hair keratin is a type of keratin found in hair and the nails. Function Originating from the embryonic epidermis, the hair follicle evolves into one of the most complex structures in the human body, comprising 7–8 distinct tissue sections. ...

to form

hair Hair is a protein filament that grows from follicles found in the dermis. Hair is one of the defining characteristics of mammals. The human body, apart from areas of glabrous skin, is covered in follicles which produce thick terminal and ...

and nails. There are two isoforms of this protein, encoded by two separate genes, ''

KRT33A Keratin, type I cuticular Ha3-I is a protein that in humans is encoded by the ''KRT33A'' gene. The protein encoded by this gene is a member of the keratin gene family. It is one of the type I hair keratin genes which are clustered in a region ...

'' and ''KRT33B'' (this gene).

References

Further reading