KIF1-binding protein, also known as Kinesin binding protein(KBP), is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''KIAA1279''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
The interaction of KBP with Kif15 is necessary for the localization of Kif15 to the microtubule plus-end at the spindle equator.
Interaction between Kif15 and KBP is essential for the perfect alignment of chromosomes at the metaphase plate, and any defect in their interaction leads to delay in chromosomal alignment during mitosis. Anything that perturb the interaction of KBP and Kif15 can block the cells at mitosis,
and hence it can be therapeutically used to control Kif15 upregulated cancer cells.
Clinical significance
Defects may be associated with
Goldberg–Shprintzen syndrome (OMIM 609460).
Interactions
KIAA1279 has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization advocating for the legal and human rights of children with intersex traits. The organization was founded in 2006 and fo ...
with
Retinal G protein coupled receptor
RPE-retinal G protein-coupled receptor also known as RGR-opsin is a protein that in humans is encoded by the ''RGR'' gene. RGR-opsin is a member of the rhodopsin-like receptor subfamily of GPCR. Like other opsins which bind retinaldehyde, it cont ...
and
Dipeptidase 1.
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]
References
Further reading
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External links
Online Mendelian Inheritance in Man entry on GOLDBERG-SHPRINTZEN MEGACOLON SYNDROME
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