KCNQ1 downstream neighbour (KCNQ1DN) is a
long non-coding RNA
Long non-coding RNAs (long ncRNAs, lncRNA) are a type of RNA, generally defined as transcripts more than 200 nucleotides that are not translated into protein. This arbitrary limit distinguishes long ncRNAs from small non-coding RNAs, such as mic ...
gene. In humans, it is located on
chromosome 11
Chromosome 11 is one of the 23 pairs of chromosomes in humans. Humans normally have two copies of this chromosome. Chromosome 11 spans about 135 million base pairs (the building material of DNA) and represents between 4 and 4.5 percent of the tota ...
p15.5 between the
CDKN1C and
KCNQ1
Kv7.1 (KvLQT1) is a potassium channel protein whose primary subunit in humans is encoded by the ''KCNQ1'' gene. Its mutation causes Long QT syndrome, Kv7.1 is a voltage and lipid-gated potassium channel present in the cell membranes of cardi ...
genes. It is an
imprinted gene, expressed from the maternal allele. Reduced expression of KCNQ1DN is observed in
Wilms' tumours.
See also
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Long noncoding RNA
Long non-coding RNAs (long ncRNAs, lncRNA) are a type of RNA, generally defined as transcripts more than 200 nucleotides that are not translated into protein. This arbitrary limit distinguishes long ncRNAs from small non-coding RNAs, such as mic ...
References
Further reading
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External links
{{Rfam, id=RF01961, name=KCNQ1 downstream neighbour
Non-coding RNA