G protein-activated inward rectifier potassium channel 1 (GIRK-1) is encoded in the human by the gene ''KCNJ3''.
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a hetero-tetrameric pore-forming complex.
Interactions
KCNJ3 has been shown to
interact with
KCNJ5.
See also
*
G protein-coupled inwardly-rectifying potassium channel
*
Inward-rectifier potassium ion channel
Inward-rectifier potassium channels (Kir, IRK) are a specific Lipid-gated_ion_channels, lipid-gated subset of potassium channels. To date, seven subfamilies have been identified in various mammalian cell types, plants, and bacteria. They are acti ...
References
Further reading
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
External links
*
Ion channels
{{membrane-protein-stub