Joseph David Brain, S.D. (born January 20, 1940) is an American

physiologist Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a sub-discipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out the chemical ...

and

environmental health Environmental health is the branch of public health concerned with all aspects of the natural and built environment affecting human health. In order to effectively control factors that may affect health, the requirements that must be met ...

researcher, who is currently the Cecil K. and Philip Drinker Professor of Environmental Physiology at

Harvard T.H. Chan School of Public Health The Harvard T.H. Chan School of Public Health is the public health school of Harvard University, located in the Longwood Medical Area of Boston, Massachusetts. The school grew out of the Harvard- MIT School for Health Officers, the nation's first ...

, where he has taught and researched for over fifty years.

Early life

Brain was born in

Paterson, New Jersey Paterson ( ) is the largest city in and the county seat of Passaic County, in the U.S. state of New Jersey.Wayne, New Jersey Wayne is a township in Passaic County, New Jersey, United States. Home to William Paterson University and located less than from Midtown Manhattan, the township is a bedroom suburb of New York City and regional commercial hub of North Jersey. A ...

, and attended

Eastern Christian High School Eastern Christian High School (ECHS) is a private Christian high school located in North Haledon, in Passaic County, New Jersey, United States. The high school is a part of the Eastern Christian School Association which also has a middle sch ...

North Haledon, New Jersey North Haledon (pronounced North HAIL-don) is a borough in Passaic County, New Jersey, United States. As of the 2010 United States Census, the borough's population was 8,417,Taylor University Taylor University is a Private university, private, Interdenominationalism, interdenominational, evangelical Christian university in Upland, Indiana. Founded in 1846, it is one of the oldest evangelical Christian universities in the country. T ...

Upland, Indiana Upland (pronounced as "up-land") is a town in Jefferson Township, Grant County, Indiana, United States. The population was 3,845 at the 2010 census. It is most notable for being the home of Taylor University, a Christian college with 2,103 stude ...

, where he majored in

physics Physics is the natural science that studies matter, its fundamental constituents, its motion and behavior through space and time, and the related entities of energy and force. "Physical science is that department of knowledge which rel ...

. After his graduation from (then)

Taylor College Lehigh University has many buildings, old and new, on its three campuses. When the university was founded in 1865, it took over several buildings from the surrounding property. One which remains today is Christmas Hall, now part of Christmas-Sau ...

, Brain was offered the

Danforth Foundation The Danforth Foundation was one of the largest private nonprofit foundations in the St. Louis Metropolitan region. It closed its doors in 2011 after 84 years of operation and more than a billion dollars in grants distributed. Background Establishe ...

Graduate Fellowship (1961-1966) at Harvard.

Education

* High School Diploma, 1957,

* S.M., 1962, Harvard Paulson School of Engineering and Applied Sciences - on

Graduate Fellowship (1961-1966) * S.M., 1963, Harvard Paulson School of Engineering and Applied Sciences - on

Graduate Fellowship (1961-1966) * S.D., 1966,

- on

Graduate Fellowship (1961-1966)

Career

Brain is currently the Cecil K. and

Philip Drinker Philip Drinker (December 12, 1894 – October 19, 1972) was an industrial hygienist. With Louis Agassiz Shaw, he invented the first widely used iron lung in 1928. Family and early life Drinker's father was railroad man and Lehigh University ...

Professor of Environmental Physiology at

, and participates in the leadership of The Lown Institute. After graduation from Taylor, Brain was offered the

Graduate Fellowship (1961-1966) at Harvard. He is involved with a five-year collaboration signed between the

University of Malaya The University of Malaya ( ms, Universiti Malaya, UM; abbreviated as UM or informally the Malayan University) is a public research university located in Kuala Lumpur, Malaysia. It is the oldest and highest ranking Malaysian institution of highe ...

(UM) and

Harvard University Harvard University is a private Ivy League research university in Cambridge, Massachusetts. Founded in 1636 as Harvard College and named for its first benefactor, the Puritan clergyman John Harvard, it is the oldest institution of high ...

in the search for more effective treatment of lung diseases through

nanomedicine Nanomedicine is the medical application of nanotechnology. Nanomedicine ranges from the medical applications of nanomaterials and biological devices, to nanoelectronic biosensors, and even possible future applications of molecular nanotec ...

. Since 1998 he has been Director of the Kresge Center for Environmental Health at Harvard. Dr. Brain was director of Respiratory Biology Program (1981-1993) and Physiology Program (1993-1997). He was also chair of the Department of Environmental Health at Harvard T.H. Chan School of Public Health (1990-2005).

Personal life

Brain is married and lives in

Essex, Massachusetts Essex is a coastal town in Essex County, Massachusetts, 26 miles (42 km) north of Boston and 13 miles (21 km) southeast of Newburyport. It is known for its former role as a center of shipbuilding. The population was 3,675 at the 2020 ce ...

. He served on the

Taylor University Taylor University is a Private university, private, Interdenominationalism, interdenominational, evangelical Christian university in Upland, Indiana. Founded in 1846, it is one of the oldest evangelical Christian universities in the country. T ...

Board of Trustees from 1988 to 2009.

Honors

U.S. Atomic Energy Commission The United States Atomic Energy Commission (AEC) was an agency of the United States government established after World War II by U.S. Congress to foster and control the peacetime development of atomic science and technology. President H ...

Fellowship in

Health Physics Health physics, also referred to as the science of radiation protection, is the profession devoted to protecting people and their environment from potential radiation hazards, while making it possible to enjoy the beneficial uses of radiation. He ...

1961-1962 * Danforth Foundation Graduate Fellowship 1961-1966 * USPHS Radiological Health Fellowship 1962-1966 * NIH Research Career Development Award 1969-1974 * Aaron Brown Lecturer (

University of Pittsburgh The University of Pittsburgh (Pitt) is a public state-related research university in Pittsburgh, Pennsylvania. The university is composed of 17 undergraduate and graduate schools and colleges at its urban Pittsburgh campus, home to the univers ...

) 1981 *

American Men and Women of Science ''American Men and Women of Science'' (the 40th edition was published in 2022) is a biographical reference work on leading scientists in the United States and Canada, published as a series of books and online by Gale. The first edition was publis ...

1982 * Alumnus of the Year,

1984 * Fellow,

American Association for the Advancement of Science The American Association for the Advancement of Science (AAAS) is an American international non-profit organization with the stated goals of promoting cooperation among scientists, defending scientific freedom, encouraging scientific responsi ...

1987 *

NIH MERIT Award The NIH MERIT award (Method To Extend Research in Time) Award (R37) was created by the National Institutes of Health The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary age ...

1987-1995 * Henry D. Chadwick Medal, Massachusetts Thoracic Society 1993 * Honorary Professor of

Huazhong University of Science and Technology The Huazhong University of Science and Technology (HUST; ) is a public research university located in Guanshan Subdistrict, Hongshan District, Wuhan, Hubei province, China. As a national key university directly affiliated to the Ministry ...

(HUST), 1999,

Wuhan, China Wuhan (, ; ; ) is the capital of Hubei Province in the People's Republic of China. It is the largest city in Hubei and the most populous city in Central China, with a population of over eleven million, the ninth-most populous Chinese city and ...

Selected publications

* Lichtenstein JHR, Molina RM, Donaghey TC, Brain JD. Strain differences influence murine pulmonary responses to Stachybotrys chartarum. Am J Respir Cell Mol Biol. 2006; 35:415-23. * Trujillo JR, Rogers R, Molina RM, Dangond F, McLane MF, Essex M, Brain JD. Non-infectious entry of HIV-1 into peripheral and brain macrophages mediated by the mannose receptor. PNAS. 2007; 104(12):5097-5102. * Molina RM and Brain JD. In vivo comparison of cat alveolar and pulmonary intravascular macrophages: phagocytosis, particle clearance, and cytoplasmic motility. Exp Lung Res. 2007; 33(2):53-70. * Brain JD, Curran MA, Donaghey T, Molina R. Responses of the lungs to nanomaterials depend on exposure, clearance, and material characteristics. Nanotoxicology. 2009; 3(1-4):173-9. * Bellows CF, Molina RM, Brain JD. Diminished organelle motion in murine Kupffer cells during the erythrocytic stage of malaria. J R Soc Interface. 2011 May 6;8(58):711-9. * Lichtenstein JHR, Molina RM, Donaghey TC, Amuzie C, Pestka JJ, Coull BA, Brain JD. Pulmonary responses to Stachybotrys chartarum and its toxins: Mouse strain affects clearance and macrophage cytotoxicity. Toxicol Sci. 2010 Jul;116(1):113-21. * Molina RM, Phattanarudee S, Kim J, Thompson K, Wessling-Resnick M, Maher TJ, Brain JD. Ingestion of Mn and Pb by rats during and after pregnancy alters behavior in offspring. NeuroToxicology. 2011; 32(4):413-22. * Thompson K, Molina R, Donaghey T, Schwob J, Brain JD. Manganese uptake and distribution in the brain after methyl bromide-induced lesions in the olfactory epithelia.Toxicol Sci. 2011 Mar;120(1):163-72. * Mendivil CO, Teeter JG, Finch GL, Schwartz PF, Riese RJ, Kawabata T, Brain JD. Trough insulin levels in bronchoalveolar lavage following inhaled human insulin (Exubera®) in patients with diabetes mellitus. Diabetes Technol Ther. 2012; 14(1):50-8. * Molina R, Schaider L, Donaghey T, Shine J, Brain JD. Mineralogy affects geoavailability, bioaccessibility and bioavailability of zinc. Environ Pollut. 2013; 182:217-24. * Pirela S, Molina R, Watson C, Cohen J, Bello, Demokritou P, Brain JD. Effects of copy center particles on the lungs: A toxicological characterization using a Balb/c mice model. Inhalation Toxicology. 2013; 25(9):498-508. * Molina RM, Konduru NV, Jimenez RJ, Wohlleben W, Brain JD. Bioavailability, distribution and clearance of tracheally instilled, gavaged or injected cerium dioxide nanoparticles and ionic cerium. Environ Sci: Nano. 2014; 1:561-73. * Brain JD, Kreyling WG, and Godleski JJ. Inhalation Toxicology. In: Hayes’ Principles and Methods of Toxicology. Sixth Edition. Edited By: A. Wallace Hayes and Claire L. Kruger. CRC Press: Boca Raton. 2014. Pages 1385–1444. * Mendivil CO, Koziel H, Brain JD. Metabolic hormones, apolipoproteins, adipokines, and cytokines in the alveolar lining fluid of healthy adults: compartmentalization and physiological correlates. PLoS One. 2015 Apr 7;10(4):e0123344 (15 pages). * Rosenblum-Lichtenstein JH, Hsu Y-H, Gavin IM, Donaghey TC, Molina RM, Thompson KJ, Chi C-L, Gillis BS, Brain JD. Environmental mold and mycotoxin exposures elicit specific cytokine and chemokine responses. PLoS One. 2015 May 26;10(5):e0126926. (22 pages) * Watson CY, Damiani F, Ram-Moham S, Rodrigues S, de Moura Queiroz P, Donaghey TC, Rosenblum Lichtenstein JH, Brain JD, Krishnan R, Molina RM. Screening for chemical toxicity using cryopreserved precision cut lung slices. Toxicological Sciences. 2016;150(1):225-33. * Rosenblum Lichtenstein JH, Molina RM, Donaghey TC, Hsu YH, Mathews JA, Kasahara DI, Park JA, Bordini A, Godleski JJ, Gillis BS, Brain JD. Repeated mouse lung exposures to Stachybotrys chartarum shift immune response from type 1 to type 2. Am J Respir Cell Mol Biol. 2016 May 5.

pub ahead of print A pub (short for public house) is a kind of drinking establishment which is licensed to serve alcoholic drinks for consumption on the premises. The term ''public house'' first appeared in the United Kingdom in late 17th century, and was ...

References

External links

Harvard-NIEHS Center for Nanotechnology and Nanotoxicology

Taylor University profile of Joseph D. Brain, Taylor alum
{{DEFAULTSORT:Brain, Joseph 1940 births Living people Harvard School of Public Health faculty American physiologists Harvard School of Engineering and Applied Sciences alumni Taylor University alumni People from Essex, Massachusetts People from Paterson, New Jersey People from Wayne, New Jersey Nanomaterials Harvard School of Public Health alumni