Jonathan Laurence Marchini (born 19 May 1973) is a Bayesian statistician and professor of statistical genomics in the Department of Statistics at the

University of Oxford The University of Oxford is a collegiate university, collegiate research university in Oxford, England. There is evidence of teaching as early as 1096, making it the oldest university in the English-speaking world and the List of oldest un ...

, a tutorial fellow in statistics at

Somerville College Somerville College is a constituent college of the University of Oxford in England. It was founded in 1879 as Somerville Hall, one of its first two women's colleges. It began admitting men in 1994. The college's liberal tone derives from its f ...

, Oxford and a co-founder and director of Gensci Ltd. He co-leads the Haplotype Reference Consortium.

Education

He obtained a Bachelor of Science degree in Pure Mathematics and Mathematical Statistics from

Exeter University The University of Exeter is a research university in the West Country of England, with its main campus in Exeter, Devon. Its predecessor institutions, St Luke's College, Exeter School of Science, Exeter School of Art, and the Camborne School o ...

(1991–94). He then obtained a PGCE in Mathematics Education from the West Sussex Institute of Higher Education (1994–95). He completed his DPhil in the Department of Statistics at the University of Oxford supervised by Professor Brian Ripley (1998–2002).

Career and research

Marchini spent three years working as a VSO volunteer teaching A-level Mathematics at Tosamaganga Secondary school, near Iringa, Tanzania, between September 1995 and September 1998. From 2002 to 2005 he held a Wellcome Trust Training Fellowship in Mathematical Biology, under the supervision of Prof Lon Cardon and Prof Peter Donnelly. In 2006 he was appointed as a university lecturer (associate professor) in statistical genomics in the Department of Statistics at the University of Oxford and a senior research fellow at Mansfield College. In 2007 he became an affiliated group leader at the Wellcome Trust Center of Human Genetics at the University of Oxford. In 2010 he was re-appointed until retirement In 2015 he was promoted to professor of statistical genomics Marchini's research focusses on

statistical genetics Statistical genetics is a scientific field concerned with the development and application of statistical methods for drawing inferences from genetic data. The term is most commonly used in the context of human genetics. Research in statistical ge ...

and

population genetics Population genetics is a subfield of genetics that deals with genetic differences within and among populations, and is a part of evolutionary biology. Studies in this branch of biology examine such phenomena as Adaptation (biology), adaptation, s ...

, with a particular emphasis on methods development for

genome-wide association studies In genomics, a genome-wide association study (GWA study, or GWAS), is an observational study of a genome-wide set of genetic variants in different individuals to see if any variant is associated with a trait. GWA studies typically focus on assoc ...

. He has worked on

haplotype estimation In genetics, haplotype estimation (also known as "phasing") refers to the process of statistical estimation of haplotypes from genotype data. The most common situation arises when genotypes are collected at a set of polymorphic sites from a group of ...

, genotype imputation, genotype calling from arrays and sequencing, sparse tensor decomposition for RNA-seq datasets, population structure, phenotype prediction and mixed models, gene–gene interactions and brain imaging genetics. He was a member of the analysis team for the

International HapMap Project The International HapMap Project was an organization that aimed to develop a haplotype map (HapMap) of the human genome, to describe the common patterns of human genetic variation. HapMap is used to find genetic variants affecting health, disease ...

, the Wellcome Trust Case-Control Consortium, the 1000 Genomes Project and the UK10K Project. His research group was responsible for the haplotype estimation and genotype imputation for the UK Biobank dataset. He co-leads the Haplotype Reference Consortium. He has been an ISI Highly Cited Researcher from 2014-2018 He has acted as an expert witness in a patent trial

Awards

In 2012 he was awarded a

Philip Leverhulme Prize The Philip Leverhulme Prize is awarded by the Leverhulme Trust to recognise the achievement of outstanding researchers whose work has already attracted international recognition and whose future career is exceptionally promising. The prize sche ...

for "leading the way by constructing powerful and ingenious novel statistical methodology for population and medical genetics, together with associated fast computational algorithms and software."

References

External links

* {{DEFAULTSORT:Marchini, Jonathan 1977 births Living people Alumni of the University of Oxford Fellows of Somerville College, Oxford British statisticians Alumni of the University of Exeter Biostatisticians