Jonathan Alan Hodgkin (born 1949) is a British

biochemist Biochemists are scientists who are trained in biochemistry. They study chemical processes and chemical transformations in living organisms. Biochemists study DNA, proteins and Cell (biology), cell parts. The word "biochemist" is a portmanteau of ...

. He is the Professor of Genetics at the

University of Oxford The University of Oxford is a collegiate university, collegiate research university in Oxford, England. There is evidence of teaching as early as 1096, making it the oldest university in the English-speaking world and the List of oldest un ...

and an

emeritus ''Emeritus/Emerita'' () is an honorary title granted to someone who retires from a position of distinction, most commonly an academic faculty position, but is allowed to continue using the previous title, as in "professor emeritus". In some c ...

fellow A fellow is a title and form of address for distinguished, learned, or skilled individuals in academia, medicine, research, and industry. The exact meaning of the term differs in each field. In learned society, learned or professional society, p ...

Keble College, Oxford Keble College () is one of the Colleges of the University of Oxford, constituent colleges of the University of Oxford in England. Its main buildings are on Parks Road, opposite the Oxford University Museum of Natural History, University Museum a ...

Education

Hodgkin was educated at the

where he graduated in 1971. He was awarded a

PhD A Doctor of Philosophy (PhD, DPhil; or ) is a terminal degree that usually denotes the highest level of academic achievement in a given discipline and is awarded following a course of graduate study and original research. The name of the deg ...

from the

University of Cambridge The University of Cambridge is a Public university, public collegiate university, collegiate research university in Cambridge, England. Founded in 1209, the University of Cambridge is the List of oldest universities in continuous operation, wo ...

in 1974 for research on the

genetics Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinians, Augustinian ...

of the worm ''

Caenorhabditis elegans ''Caenorhabditis elegans'' () is a free-living transparent nematode about 1 mm in length that lives in temperate soil environments. It is the type species of its genus. The name is a Hybrid word, blend of the Greek ''caeno-'' (recent), ''r ...

''.

Career and research

Hodgkin was a scientist at the Medical Research Council (MRC)

Laboratory of Molecular Biology The Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) is a research institute in Cambridge, England, involved in the revolution in molecular biology which occurred in the 1950–60s. Since then it has remained a major medical r ...

in Cambridge. Hodgkin was one of the earliest researchers to explore the genetics of development in the nematode worm ''

''. He first unraveled the genetic and maturational events in worm sex determination before extending his interest to other developmental pathways, behaviour and immunity. Most ''Caenorhabditis elegans'' worms are self-fertilizing

hermaphrodite A hermaphrodite () is a sexually reproducing organism that produces both male and female gametes. Animal species in which individuals are either male or female are gonochoric, which is the opposite of hermaphroditic. The individuals of many ...

s, with two

X chromosome The X chromosome is one of the two sex chromosomes in many organisms, including mammals, and is found in both males and females. It is a part of the XY sex-determination system and XO sex-determination system. The X chromosome was named for its u ...

s, but X0 males can also arise spontaneously, permitting genetic crosses. Hodgkin used genetic

mutation In biology, a mutation is an alteration in the nucleic acid sequence of the genome of an organism, virus, or extrachromosomal DNA. Viral genomes contain either DNA or RNA. Mutations result from errors during DNA or viral replication, ...

s in this tiny, fast-breeding species to define the regulatory cascade of genes that controls the development of male or hermaphrodite characteristics providing a model for approaching development in other species. Since 2000, Hodgkin has focused on the nematode's response to attack by bacteria, exploring highly conserved pathways of innate immunity that are also relevant to development. Through

microarray A microarray is a multiplex (assay), multiplex lab-on-a-chip. Its purpose is to simultaneously detect the expression of thousands of biological interactions. It is a two-dimensional array on a Substrate (materials science), solid substrate—usu ...

analysis, he has identified

antibacterial An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting bacterial infections, and antibiotic medications are widely used in the treatment and prevention ...

factors produced by the worm that could be candidates for new antibiotics. He has also discovered novel

pathogenic bacteria Pathogenic bacteria are bacteria that can cause disease. This article focuses on the bacteria that are pathogenic to humans. Most species of bacteria are harmless and many are Probiotic, beneficial but others can cause infectious diseases. The nu ...

that attack nematodes, which may have potential as

biological pest control Biological control or biocontrol is a method of controlling pests, whether pest animals such as insects and mites, weeds, or pathogens affecting animals or plants by using other organisms. It relies on predation, parasitism, herbivory, or ot ...

agents against parasitic nematodes.

Awards and honours

Hodgkin was elected a

Fellow of the Royal Society Fellowship of the Royal Society (FRS, ForMemRS and HonFRS) is an award granted by the Fellows of the Royal Society of London to individuals who have made a "substantial contribution to the improvement of natural science, natural knowledge, incl ...

(FRS) in 1990. One or more of the preceding sentences incorporates text from the royalsociety.org website where: In 2011, he received

The Genetics Society The Genetics Society is a British learned society. It was founded by William Bateson and Edith Rebecca Saunders in 1919 and celebrated its centenary year in 2019. It is therefore one of the oldest learned societies devoted to genetics. Its membe ...

Medal. Hodgkin was a member of the

Faculty of 1000 F1000 (formerly "Faculty of 1000") is an open research publisher for scientists, scholars, and clinical researchers. F1000 offers a different research evaluation service from standard academic journals by offering peer-review after, rather than ...

. He was awarded the Edward Novitski Prize by the

Genetics Society of America The Genetics Society of America (GSA) is a scholarly membership society of more than 5,500 genetics researchers and educators, established in 1931. The Society was formed from the reorganization of the Joint Genetics Sections of the American Soc ...

in 2017.

Personal life

Hodgkin is the son of Nobel laureate Alan Lloyd Hodgkin and the editor Marni Hodgkin.

References

{{DEFAULTSORT:Hodgkin, Jonathan British biochemists Professors of Genetics (University of Oxford) Fellows of Keble College, Oxford Fellows of the Royal Society Jonathan Living people 1949 births Caenorhabditis elegans Fellows of Merton College, Oxford Alumni of the University of Oxford