John W. Drake (February 10, 1932 – February 2, 2020) was an

American American(s) may refer to: * American, something of, from, or related to the United States of America, commonly known as the "United States" or "America" ** Americans, citizens and nationals of the United States of America ** American ancestry, p ...

microbiologist A microbiologist (from Greek ) is a scientist who studies microscopic life forms and processes. This includes study of the growth, interactions and characteristics of microscopic organisms such as bacteria, algae, fungi, and some types of par ...

and

geneticist A geneticist is a biologist or physician who studies genetics, the science of genes, heredity, and variation of organisms. A geneticist can be employed as a scientist or a lecturer. Geneticists may perform general research on genetic process ...

, working for over half a century in the field of

mutagenesis Mutagenesis () is a process by which the genetic information of an organism is changed by the production of a mutation. It may occur spontaneously in nature, or as a result of exposure to mutagens. It can also be achieved experimentally using lab ...

and

DNA repair DNA repair is a collection of processes by which a cell (biology), cell identifies and corrects damage to the DNA molecules that encode its genome. A weakened capacity for DNA repair is a risk factor for the development of cancer. DNA is cons ...

Education and early career

He completed an MS in Microbiology at the

University of Illinois The University of Illinois Urbana-Champaign (UIUC, U of I, Illinois, or University of Illinois) is a public university, public land-grant university, land-grant research university in the Champaign–Urbana metropolitan area, Illinois, United ...

(with Paul M. Bingham). His interest in

embryology Embryology (from Ancient Greek, Greek ἔμβρυον, ''embryon'', "the unborn, embryo"; and -λογία, ''-logy, -logia'') is the branch of animal biology that studies the Prenatal development (biology), prenatal development of gametes (sex ...

led him to take his PhD at the

California Institute of Technology The California Institute of Technology (branded as Caltech) is a private research university in Pasadena, California, United States. The university is responsible for many modern scientific advancements and is among a small group of institutes ...

in 1958 where he studied alongside

Howard Temin Howard Martin Temin (December 10, 1934 – February 9, 1994) was an American geneticist and virologist. He discovered reverse transcriptase in the 1970s at the University of Wisconsin–Madison, for which he shared the 1975 Nobel Prize in Phys ...

in the laboratory of

Renato Dulbecco Renato Dulbecco ( , ; February 22, 1914 – February 19, 2012) was an Italian–American virologist who won the 1975 Nobel Prize in Physiology or Medicine for his work on oncoviruses, which are viruses that can cause cancer when they infect anim ...

Research interests and career

Based on earlier observations on the mutation frequencies of the

bacteriophage T4 Escherichia virus T4 is a species of bacteriophages that infect ''Escherichia coli'' bacteria. It is a double-stranded DNA virus in the subfamily '' Tevenvirinae'' of the family '' Straboviridae''. T4 is capable of undergoing only a lytic li ...

, Drake in the early 1960s began to study the biochemical activities of the T4 polymerase. For this, he established a phage genetics laboratory at the

. Together with his coworkers he could dissect both pro- and anti-mutagenic activities of the T4 DNA polymerases during

viral replication Viral replication is the formation of biological viruses during the infection process in the target host cells. Viruses must first get into the cell before viral replication can occur. Through the generation of abundant copies of its genome ...

. To describe the mutation rate in a quantitative way for different organisms, Drake postulated that the mutation rate (per base position and per replication cycle) is proportional to the total genome size of a DNA-based microorganism ("Drakes Law"). His own discovery of mutator phenotypes (i.e. bacterial or phage strains which display an exceptionally high mutation rate), however demonstrated that there can be deviations (hypermutability) from this general rule. As an early member of the

Environmental Mutagen Society The Environmental Mutagenesis and Genomics Society (EMGS) is a scientific society "for the promotion of critical scientific knowledge and research into the causes and consequences of damage to the genome and epigenome in order to inform and suppor ...

, John W. Drake chaired its "Committee 17" which published an influential position paper; “Environmental Mutagenic Hazards”, in

Science Science is a systematic discipline that builds and organises knowledge in the form of testable hypotheses and predictions about the universe. Modern science is typically divided into twoor threemajor branches: the natural sciences, which stu ...

in 1975. This described the research needs and regulatory responsibility for managing potential mutagenic compounds in the environment. It significantly influenced research direction, regulatory procedures and mutagenicity testing within industry within the United States and internationally. Later, he pioneered research on the mutational processes during replication of RNA viruses and RNA bacteriophages. Results from these studies had far reaching consequences for the understanding of the mechanisms that drive viral evolution of human pathogens such as

Influenza A virus ''Influenza A virus'' (''Alphainfluenzavirus influenzae'') or IAV is the only species of the genus ''Alphainfluenzavirus'' of the virus family '' Orthomyxoviridae''. It is a pathogen with strains that infect birds and some mammals, as well as c ...

Hepatitis C virus The hepatitis C virus (HCV) is a small (55–65 nm in size), enveloped, positive-sense single-stranded RNA virus of the family ''Flaviviridae''. The hepatitis C virus is the cause of hepatitis C and some cancers such as liver cancer ( hepatoc ...

and SARS coronavirus 2. As editor-in-chief of

GENETICS Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinians, Augustinian ...

from 1982 to 1996, Jan Drake helped to make the journal a first-choice for scientific publications from all over the world. In the last years of his academic and scientific career, John W. Drake headed the Spontaneous Mutation and DNA Repair Group within the Laboratory of Molecular Genetics at the

National Institute of Environmental Health Sciences The National Institute of Environmental Health Sciences (NIEHS) conducts research into the effects of the environment on human disease, as one of the 27 institutes and centers of the National Institutes of Health (NIH). It is located in the Rese ...

. He was fellow of the

John Simon Guggenheim Memorial Foundation The John Simon Guggenheim Memorial Foundation is a private foundation formed in 1925 by Olga and Simon Guggenheim in memory of their son, who died on April 26, 1922. The organization awards Guggenheim Fellowship Guggenheim Fellowships are Gr ...

Selected publications

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References

{{DEFAULTSORT:Drake, John W. 1932 births 2020 deaths American geneticists University of Illinois Urbana-Champaign alumni California_Institute_of_Technology_alumni Genetics (journal) editors