John Stanley Griffith (1928–1972) was a British chemist, mathematician and

biophysicist Biophysics is an interdisciplinary science that applies approaches and methods traditionally used in physics to study biological phenomena. Biophysics covers all scales of biological organization, from molecular to organismic and populations ...

. He was the nephew of the distinguished British

bacteriologist A bacteriologist is a microbiologist, or similarly trained professional, in bacteriology— a subdivision of microbiology that studies bacteria, typically Pathogenic bacteria, pathogenic ones. Bacteriologists are interested in studying and learnin ...

Frederick Griffith Frederick Griffith (1877–1941) was a British bacteriologist whose focus was the epidemiology and pathology of bacterial pneumonia. In January 1928 he reported what is now known as Griffith's experiment, the first widely accepted demonstrat ...

Career

Beginning as an undergraduate in mathematics at

Trinity College, Cambridge Trinity College is a Colleges of the University of Cambridge, constituent college of the University of Cambridge. Founded in 1546 by King Henry VIII, Trinity is one of the largest Cambridge colleges, with the largest financial endowment of any ...

in 1946–1949, he went on to read Part II biochemistry in 1949–1951. His research career continued in theoretical chemistry at Oxford and Cambridge, where he held a Berry-Ramsey research fellowship at King's College. He had several appointments in Britain and the US in his different disciplines. These included professorships in chemistry at

Indiana University Bloomington Indiana University Bloomington (IU Bloomington, Indiana University, IU, IUB, or Indiana) is a public university, public research university in Bloomington, Indiana, United States. It is the flagship university, flagship campus of Indiana Univer ...

and at the

University of Pennsylvania The University of Pennsylvania (Penn or UPenn) is a Private university, private Ivy League research university in Philadelphia, Pennsylvania, United States. One of nine colonial colleges, it was chartered in 1755 through the efforts of f ...

, where he received the Marlow Award of the

Royal Society of Chemistry The Royal Society of Chemistry (RSC) is a learned society and professional association in the United Kingdom with the goal of "advancing the chemistry, chemical sciences". It was formed in 1980 from the amalgamation of the Chemical Society, the ...

in 1961. He then spent time at the Department of Mathematics at

UMIST The University of Manchester Institute of Science and Technology (UMIST) was a university based in the centre of the city of Manchester in England. It specialised in technical and scientific subjects and was a major centre for Research univer ...

Manchester Manchester () is a city and the metropolitan borough of Greater Manchester, England. It had an estimated population of in . Greater Manchester is the third-most populous metropolitan area in the United Kingdom, with a population of 2.92&nbs ...

. In 1967 he was appointed to a chair in the Department of Mathematics of

Bedford College, London Bedford College was founded in London in 1849 as the first higher education college for women in the United Kingdom. In 1900, it became a constituent of the University of London. Having played a leading role in the advancement of women in highe ...

, where his inaugural lecture was entitled "The Neural Basis of Conscious Decision". In 1968 he moved back to the Department of Chemistry at Bloomington.

Research

His early work was in the

inorganic chemistry Inorganic chemistry deals with chemical synthesis, synthesis and behavior of inorganic compound, inorganic and organometallic chemistry, organometallic compounds. This field covers chemical compounds that are not carbon-based, which are the subj ...

transition metal In chemistry, a transition metal (or transition element) is a chemical element in the d-block of the periodic table (groups 3 to 12), though the elements of group 12 (and less often group 3) are sometimes excluded. The lanthanide and actinid ...

ions and

ligand field theory Ligand field theory (LFT) describes the bonding, orbital arrangement, and other characteristics of coordination complexes. It represents an application of molecular orbital theory to transition metal complexes. A transition metal ion has nine vale ...

. During the 1960s, Griffith and radiation biologist

Tikvah Alper Tikvah Alper (22 January 1909 – 2 February 1995) trained as a physicist and became a distinguished radiobiologist. Among many other initiatives and discoveries, she was among the first to find evidence indicating that the infectious agent ...

developed the hypothesis that some

transmissible spongiform encephalopathies Transmissible spongiform encephalopathies (TSEs), also known as prion diseases, are a group of progressive, incurable, and fatal conditions that are associated with the prion hypothesis and affect the brain and nervous system of many animals, in ...

(TSEs) are caused by an infectious agent consisting solely of proteins. This idea was eventually developed by Prusiner and others into the so-called

prion A prion () is a Proteinopathy, misfolded protein that induces misfolding in normal variants of the same protein, leading to cellular death. Prions are responsible for prion diseases, known as transmissible spongiform encephalopathy (TSEs), w ...

hypothesis. In 1951, when he was just 23, at Francis Crick's suggestion, Griffith performed quantum mechanical calculations on what later became known as ''complementary base pairing''. Griffith has published several books, including "The Theory of Transition-Metal Ions" (1961), "The Irreducible Tensor Method for Molecular Symmetry Groups" (1962), and "Mathematical Neurobiology: An Introduction to the Mathematics of the Nervous System" (1971).

References

1928 births 1972 deaths British chemists British biophysicists Alumni of Trinity College, Cambridge {{UK-chemist-stub

Career

Research

See also

References