John R. Yates III is an American chemist and Ernest W. Hahn Professor in the Departments of Molecular Medicine and Neurobiology at

The Scripps Research Institute Scripps Research is a nonprofit American medical research facility that focuses on research and education in the biomedical sciences. Headquartered in San Diego, California, the institute has over 170 laboratories employing 2,100 scientists, tec ...

La Jolla, California La Jolla ( , ) is a hilly, seaside neighborhood in San Diego, California, occupying of curving coastline along the Pacific Ocean. The population reported in the 2010 census was 46,781. The climate is mild, with an average daily temperature o ...

. He is currently editor-in-chief of the

Journal of Proteome Research The ''Journal of Proteome Research'' is a peer-reviewed scientific journal published since 2002 by the American Chemical Society. Its publication frequency switched from bimonthly to monthly in 2006. The current editor-in-chief is John R. Yates. ...

. He appeared on list of 2022, 2023 and 2024 Highly Cited Researchers, making him among the top one percent of most cited researchers in the world. His work is focused on developing tools and in

proteomics Proteomics is the large-scale study of proteins. Proteins are vital macromolecules of all living organisms, with many functions such as the formation of structural fibers of muscle tissue, enzymatic digestion of food, or synthesis and replicatio ...

and he specializes in

mass spectrometry Mass spectrometry (MS) is an analytical technique that is used to measure the mass-to-charge ratio of ions. The results are presented as a ''mass spectrum'', a plot of intensity as a function of the mass-to-charge ratio. Mass spectrometry is used ...

. He is best known for the development of the

Sequest Sequest (often stylized as SEQUEST) is a tandem mass spectrometry data analysis program used for protein identification. Sequest identifies collections of tandem mass spectra to peptide sequences that have been generated from databases of protei ...

algorithm for automated peptide sequencing and Multidimensional Protein Identification Technology (MudPIT) and

data-independent acquisition In mass spectrometry, data-independent acquisition (DIA) is a method of molecular structure determination in which all ions within a selected '' m/z'' range are fragmented and analyzed in a second stage of tandem mass spectrometry. Tandem mass spect ...

. His lab is known for its contribution to methods to identify structural changes in proteins in living cells as well as method to identify N -glycan processing and occupancy using mass spectrometry such as covalent protein painting, and DeGlyPHER (Deglycosylation-dependent Glycan/Proteomic Heterogeneity Evaluation Report). His laboratory has made important contributions to understanding the biochemical mechanisms behind the failure of △F508 cystic fibrosis ion transport regulator to mature.

References

External links

Page at Scripps

Lab page
21st-century American chemists Mass spectrometrists Living people Scripps Research faculty Year of birth missing (living people) Thomson Medal recipients {{US-academic-scientist-stub