John Jefferson may refer to:
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John Jefferson (missionary) (1760–1807), English missionary
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Joseph John Jefferson (1795–1882), English Congregationalist minister and Christian pacifist
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John Wayles Jefferson (1835–1892), American businessman and Union Army officer
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John Jefferson (American football) (born 1956), American football player
See also
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Jon Jefferson (born 1955), American author and television documentary maker
{{hndis, Jefferson, John