Johannes Orth (14 January 1847 – 13 January 1923 in Berlin) was a German

pathologist Pathology is the study of disease. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when used in the context of modern medical treatme ...

born in Wallmerod. He studied medicine at the universities of

Heidelberg Heidelberg (; ; ) is the List of cities in Baden-Württemberg by population, fifth-largest city in the States of Germany, German state of Baden-Württemberg, and with a population of about 163,000, of which roughly a quarter consists of studen ...

Würzburg Würzburg (; Main-Franconian: ) is, after Nuremberg and Fürth, the Franconia#Towns and cities, third-largest city in Franconia located in the north of Bavaria. Würzburg is the administrative seat of the Regierungsbezirk Lower Franconia. It sp ...

and

Bonn Bonn () is a federal city in the German state of North Rhine-Westphalia, located on the banks of the Rhine. With a population exceeding 300,000, it lies about south-southeast of Cologne, in the southernmost part of the Rhine-Ruhr region. This ...

, receiving his

habilitation Habilitation is the highest university degree, or the procedure by which it is achieved, in Germany, France, Italy, Poland and some other European and non-English-speaking countries. The candidate fulfills a university's set criteria of excelle ...

in 1872 while an assistant to Eduard von Rindfleisch at Bonn. Afterwards, he served as an assistant under

Rudolf Virchow Rudolf Ludwig Carl Virchow ( ; ; 13 October 18215 September 1902) was a German physician, anthropologist, pathologist, prehistorian, biologist, writer, editor, and politician. He is known as "the father of modern pathology" and as the founder o ...

(1821-1902) in

Berlin Berlin ( ; ) is the Capital of Germany, capital and largest city of Germany, by both area and List of cities in Germany by population, population. With 3.7 million inhabitants, it has the List of cities in the European Union by population withi ...

. In 1878 he became a professor at the

University of Göttingen The University of Göttingen, officially the Georg August University of Göttingen (, commonly referred to as Georgia Augusta), is a Public university, public research university in the city of Göttingen, Lower Saxony, Germany. Founded in 1734 ...

, and in 1902, following the death of Virchow, he returned to Berlin as director of the clinic of pathology. Orth specialized in the pathological study of

infectious disease An infection is the invasion of tissue (biology), tissues by pathogens, their multiplication, and the reaction of host (biology), host tissues to the infectious agent and the toxins they produce. An infectious disease, also known as a transmis ...

s, particularly

tuberculosis Tuberculosis (TB), also known colloquially as the "white death", or historically as consumption, is a contagious disease usually caused by ''Mycobacterium tuberculosis'' (MTB) bacteria. Tuberculosis generally affects the lungs, but it can al ...

and

endocarditis Endocarditis is an inflammation of the inner layer of the heart, the endocardium. It usually involves the heart valves. Other structures that may be involved include the interventricular septum, the chordae tendineae, the mural endocardium, o ...

. In 1875, he documented an account involving an

autopsy An autopsy (also referred to as post-mortem examination, obduction, necropsy, or autopsia cadaverum) is a surgical procedure that consists of a thorough examination of a corpse by dissection to determine the cause, mode, and manner of deat ...

of a jaundiced infant with intense yellow staining of the

basal ganglia The basal ganglia (BG) or basal nuclei are a group of subcortical Nucleus (neuroanatomy), nuclei found in the brains of vertebrates. In humans and other primates, differences exist, primarily in the division of the globus pallidus into externa ...

hippocampus The hippocampus (: hippocampi; via Latin from Ancient Greek, Greek , 'seahorse'), also hippocampus proper, is a major component of the brain of humans and many other vertebrates. In the human brain the hippocampus, the dentate gyrus, and the ...

, the

third ventricle The third ventricle is one of the four connected cerebral ventricles of the ventricular system within the mammalian brain. It is a slit-like cavity formed in the diencephalon between the two thalami, in the midline between the right and lef ...

, as well as parts of the

cerebellum The cerebellum (: cerebella or cerebellums; Latin for 'little brain') is a major feature of the hindbrain of all vertebrates. Although usually smaller than the cerebrum, in some animals such as the mormyrid fishes it may be as large as it or eve ...

. However, it wouldn't be until the early 20th century that this condition would be further comprehended. In 1903, pathologist Christian Georg Schmorl (1861-1932) presented the results of 120 autopsies of jaundiced infants, with six of the cases having the staining phenomena described by Orth. Schmorl coined the term "

kernicterus Kernicterus is a bilirubin-induced brain dysfunction. The term was coined in 1904 by Christian Georg Schmorl. Bilirubin is a naturally occurring substance in the body of humans and many other animals, but it is neurotoxic when its concentration ...

" (

jaundice Jaundice, also known as icterus, is a yellowish or, less frequently, greenish pigmentation of the skin and sclera due to high bilirubin levels. Jaundice in adults is typically a sign indicating the presence of underlying diseases involving ...

of the

) for the yellow staining phenomenon.

Selected writings

* ''Ueber das Vorkommen von bilirubinkrystallen bei neugeborenen kindern''; in Virchow's Archiv Pathol. Anat. 63:447–462. (1875). * ''Compendium der pathologisch-anatomischen Diagnostik'' (1894) - Compendium of pathologic-anatomical diagnostics. * ''Cursus der normalen Histologie'' - Cursus of normal

histology Histology, also known as microscopic anatomy or microanatomy, is the branch of biology that studies the microscopic anatomy of biological tissue (biology), tissues. Histology is the microscopic counterpart to gross anatomy, which looks at large ...

. * ''Lehrbuch der speciellen pathologischen Anatomie'' - Textbook of special pathological anatomy.
Pagel: Biographisches Lexikon hervorragender Ärzte des neunzehnten Jahrhunderts. Berlin, Wien 1901, Sp. 1236.

References

Pioneers in the Scientific Study of Neonatal Jaundice and Kernicterus * ''This article incorporates translated text from an equivalent article at the

German Wikipedia The German Wikipedia () is the German-language edition of Wikipedia, a free and publicly editable online encyclopedia. Founded on 16 March 2001, it is the second-oldest Wikipedia edition (after the English Wikipedia). It has articles, ma ...

''. {{DEFAULTSORT:Orth, Johannes 1847 births 1923 deaths People from Westerwaldkreis German pathologists University of Bonn alumni Academic staff of the University of Göttingen People from Hesse-Nassau