Johan Auwerx (born 1958 in

Diepenbeek Diepenbeek (; ) is a municipality located in the Belgian province of Limburg near Hasselt. On January 1, 2012, Diepenbeek had a total population of 18,337. Its total area is which gives a population density Population density (in agriculture: ...

Belgium Belgium, officially the Kingdom of Belgium, is a country in Northwestern Europe. Situated in a coastal lowland region known as the Low Countries, it is bordered by the Netherlands to the north, Germany to the east, Luxembourg to the southeas ...

) is a Belgian biologist, and a professor at the

École Polytechnique Fédérale de Lausanne The École Polytechnique Fédérale de Lausanne (, EPFL) is a public university, public research university in Lausanne, Switzerland, founded in 1969 with the mission to "train talented engineers in Switzerland". Like its sister institution E ...

(EPFL). His research in the fields of

cellular metabolism Metabolism (, from ''metabolē'', "change") is the set of life-sustaining chemical reactions in organisms. The three main functions of metabolism are: the conversion of the energy in food to energy available to run cellular processes; the co ...

has contributed to a better understanding of the regulation of

mitochondrial A mitochondrion () is an organelle found in the cells of most eukaryotes, such as animals, plants and fungi. Mitochondria have a double membrane structure and use aerobic respiration to generate adenosine triphosphate (ATP), which is used ...

function by

signaling pathways Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events. Proteins responsible for detecting stimuli are generally termed receptors, although in some cases the term ...

Career

Johan Auwerx studied medicine at the

Université catholique de Louvain UCLouvain (or Université catholique de Louvain , French for Catholic University of Louvain, officially in English the University of Louvain) is Belgium's largest French-speaking university and one of the oldest in Europe (originally establishe ...

and received his doctoral degree in 1982. He then worked as a

post-doctoral A postdoctoral fellow, postdoctoral researcher, or simply postdoc, is a person professionally conducting research after the completion of their doctoral studies (typically a PhD). Postdocs most commonly, but not always, have a temporary academ ...

researcher at the

University of Washington The University of Washington (UW and informally U-Dub or U Dub) is a public research university in Seattle, Washington, United States. Founded in 1861, the University of Washington is one of the oldest universities on the West Coast of the Uni ...

Seattle Seattle ( ) is the most populous city in the U.S. state of Washington and in the Pacific Northwest region of North America. With a population of 780,995 in 2024, it is the 18th-most populous city in the United States. The city is the cou ...

, and was appointed professor at the

Louis Pasteur University Louis Pasteur University (, ULP), also known as Strasbourg I, was a large university in Strasbourg, Alsace, France. As of 15 January 2007, there were 18,847 students enrolled at the university, including around 3,000 foreign students. Researc ...

Strasbourg Strasbourg ( , ; ; ) is the Prefectures in France, prefecture and largest city of the Grand Est Regions of France, region of Geography of France, eastern France, in the historic region of Alsace. It is the prefecture of the Bas-Rhin Departmen ...

, and at the

École polytechnique fédérale de Lausanne The École Polytechnique Fédérale de Lausanne (, EPFL) is a public university, public research university in Lausanne, Switzerland, founded in 1969 with the mission to "train talented engineers in Switzerland". Like its sister institution E ...

in 2008. He leads the Laboratory of Integrative Systems Physiology (LISP) and occupies the

Nestlé Nestlé S.A. ( ) is a Swiss multinational food and drink processing conglomerate corporation headquartered in Vevey, Switzerland. It has been the largest publicly held food company in the world, measured by revenue and other metrics, since 20 ...

chair on energy metabolism. Johan Auwerx's lab studies how factors such as

diet Diet may refer to: Food * Diet (nutrition), the sum of the food consumed by an organism or group * Dieting, the deliberate selection of food to control body weight or nutrient intake ** Diet food, foods that aid in creating a diet for weight loss ...

physical exercise Exercise or workout is physical activity that enhances or maintains fitness and overall health. It is performed for various reasons, including weight loss or maintenance, to aid growth and improve strength, develop muscles and the cardio ...

hormones A hormone (from the Greek participle , "setting in motion") is a class of signaling molecules in multicellular organisms that are sent to distant organs or tissues by complex biological processes to regulate physiology and behavior. Hormones a ...

regulate

metabolism Metabolism (, from ''metabolē'', "change") is the set of life-sustaining chemical reactions in organisms. The three main functions of metabolism are: the conversion of the energy in food to energy available to run cellular processes; the co ...

by altering

gene expression Gene expression is the process (including its Regulation of gene expression, regulation) by which information from a gene is used in the synthesis of a functional gene product that enables it to produce end products, proteins or non-coding RNA, ...

through modulating the activity of

transcription factors In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. The fun ...

and co-factors.

Distinctions

Johan Auwerx was elected as an

EMBO Embo or EMBO may refer to: *Embo, Taguig, a grouping of barangays in Taguig, Philippines * Embo (''Star Wars''), a ''Star Wars'' fictional character *Embo S.p.A., an Italian automotive manufacturer *Embo, Sutherland, a village in Highland, Scotland ...

member in 2003. In 2016, he was awarded the

Marcel Benoist Prize The Marcel Benoist Prize, offered by the Marcel Benoist Foundation, is a monetary prize that has been offered annually since 1920 to a scientist of Swiss nationality or residency who has made the most useful scientific discovery. Emphasis is pl ...

for his work on

mitochondria A mitochondrion () is an organelle found in the cells of most eukaryotes, such as animals, plants and fungi. Mitochondria have a double membrane structure and use aerobic respiration to generate adenosine triphosphate (ATP), which is us ...

and their role in

, and more specifically on how

nutrients A nutrient is a substance used by an organism to survive, grow and reproduce. The requirement for dietary nutrient intake applies to animals, plants, fungi and protists. Nutrients can be incorporated into cells for metabolic purposes or excret ...

can influence cellular behavior, thereby initiating fat cell breakdown or preventing

metabolic disorders A metabolic disorder is a disorder that negatively alters the body's processing and distribution of macronutrients, such as proteins, fats, and carbohydrates. Metabolic disorders can happen when abnormal chemical reactions in the body alter the ...

. Johan Auwerx was awarded several other prizes, such as the

Danone Danone S.A. () is a French multinational corporation, multinational food-products corporation based in Paris. It was founded in 1919 in Barcelona, Barcelona, Spain. It is listed on Euronext Paris, where it is a component of the CAC 40 stock mark ...

International prize for nutrition (2008), the Oskar Minkowski Prize (1998) and the Morgagni Gold Medal. He is on the editorial board of journals such as ''

Science Science is a systematic discipline that builds and organises knowledge in the form of testable hypotheses and predictions about the universe. Modern science is typically divided into twoor threemajor branches: the natural sciences, which stu ...

'', ''

Cell Metabolism ''Cell Metabolism'' is a monthly peer-reviewed scientific journal covering physiology, with an emphasis on understanding the molecular basis of how the body self-regulates in the face of change, and how disturbances in these balances can lead to di ...

'', ''

The EMBO Journal ''The EMBO Journal'' is a semi-monthly peer-reviewed scientific journal focusing on full-length papers describing original research of general interest in molecular biology and related areas. The editor-in-chief is Facundo D. Batista ( Harvard Medi ...

'' and ''

The Journal of Cell Biology ''The'' is a grammatical article in English, denoting nouns that are already or about to be mentioned, under discussion, implied or otherwise presumed familiar to listeners, readers, or speakers. It is the definite article in English. ''The ...

''. As of 2020, his publications have been cited more than 100,000 times and his

h-index The ''h''-index is an author-level metric that measures both the productivity and citation impact of the publications, initially used for an individual scientist or scholar. The ''h''-index correlates with success indicators such as winning t ...

is 166. He is therefore a highly cited researcher, according to the

Institute for Scientific Information The Institute for Scientific Information (ISI) was an academic publishing service, founded by Eugene Garfield in Philadelphia in 1956. ISI offered scientometric and bibliographic database services. Its specialty was citation indexing and analysis, ...

References

20th-century Belgian biologists 1958 births Living people {{Belgium-scientist-stub