Joan Oró i Florensa, 1st Marquess of Oró (; 26 October 1923 – 2 September 2004) was a Spanish (Catalan)
biochemist
Biochemists are scientists who are trained in biochemistry. They study chemical processes and chemical transformations in living organisms. Biochemists study DNA, proteins and Cell (biology), cell parts. The word "biochemist" is a portmanteau of ...
, whose research has been of importance in understanding the
origin of life
Abiogenesis is the natural process by which life arises from abiotic component, non-living matter, such as simple organic compounds. The prevailing scientific hypothesis is that the transition from non-living to organism, living entities on ...
. Living in the United States for many years, he participated in several NASA missions, including the
Apollo mission to the
Moon
The Moon is Earth's only natural satellite. It Orbit of the Moon, orbits around Earth at Lunar distance, an average distance of (; about 30 times Earth diameter, Earth's diameter). The Moon rotation, rotates, with a rotation period (lunar ...
and the
Viking lander. He received the
Oparin Medal for his contributions to the field of
origins of life.
Early life and education
Joan Oró i Florensa was born on 26 October 1923, in
Lleida
Lleida (, ; ; '' see below'') is a city in the west of Catalonia, Spain. It is the capital and largest town in Segrià county, the Ponent region and the province of Lleida. Geographically, it is located in the Catalan Central Depression. It ...
,
Catalonia
Catalonia is an autonomous community of Spain, designated as a ''nationalities and regions of Spain, nationality'' by its Statute of Autonomy of Catalonia of 2006, Statute of Autonomy. Most of its territory (except the Val d'Aran) is situate ...
, Spain, the youngest of five children.
[
After completing secondary school late owing to the ]Spanish Civil War
The Spanish Civil War () was a military conflict fought from 1936 to 1939 between the Republican faction (Spanish Civil War), Republicans and the Nationalist faction (Spanish Civil War), Nationalists. Republicans were loyal to the Left-wing p ...
, he completed his undergraduate studies in chemistry
Chemistry is the scientific study of the properties and behavior of matter. It is a physical science within the natural sciences that studies the chemical elements that make up matter and chemical compound, compounds made of atoms, molecules a ...
, focusing on organic chemistry
Organic chemistry is a subdiscipline within chemistry involving the science, scientific study of the structure, properties, and reactions of organic compounds and organic matter, organic materials, i.e., matter in its various forms that contain ...
, at the University of Barcelona
The University of Barcelona (official name in ; UB), formerly also known as Central University of Barcelona (), is a public research university located in the city of Barcelona, Catalonia, Spain. It was established in 1450. With 76,000 students, ...
in 1947. He first tried to earn a living as a chemist, but that did not work, so he spent three years working at his father's bakery and saving money.[
After getting married and having children, he and his family moved to the United States in 1952, due to the scarce scientific resources offered by the Spanish academia at that time. He enrolled at the Rice Institute in ]Houston, Texas
Houston ( ) is the List of cities in Texas by population, most populous city in the U.S. state of Texas and in the Southern United States. Located in Southeast Texas near Galveston Bay and the Gulf of Mexico, it is the county seat, seat of ...
, and started doing graduate studies in chemical engineering
Chemical engineering is an engineering field which deals with the study of the operation and design of chemical plants as well as methods of improving production. Chemical engineers develop economical commercial processes to convert raw materials ...
. After working with Donald Rappoport, who was professor of biochemistry at Baylor College of Medicine
The Baylor College of Medicine (BCM) is a private medical school in Houston, Texas, United States. Originally as the Baylor University College of Medicine from 1903 to 1969, the college became independent with the current name and has been se ...
, he switched to biochemistry, and in 1956 he obtained his PhD in biochemistry in Houston
Houston ( ) is the List of cities in Texas by population, most populous city in the U.S. state of Texas and in the Southern United States. Located in Southeast Texas near Galveston Bay and the Gulf of Mexico, it is the county seat, seat of ...
.[
]
Scientific and academic career
Oró became a full professor in University of Houston in 1963 where he founded and directed the department of biochemistry and biophysics. From the 1960s he worked with NASA
The National Aeronautics and Space Administration (NASA ) is an independent agencies of the United States government, independent agency of the federal government of the United States, US federal government responsible for the United States ...
on the Viking missions which explored the planet Mars
Mars is the fourth planet from the Sun. It is also known as the "Red Planet", because of its orange-red appearance. Mars is a desert-like rocky planet with a tenuous carbon dioxide () atmosphere. At the average surface level the atmosph ...
. His work was essential in the analysis of samples of Martian soil, questioning early suggestions that life might have been detected.[
]
Origins of life
One of his most important contributions was the prebiotic synthesis of the nucleobase
Nucleotide bases (also nucleobases, nitrogenous bases) are nitrogen-containing biological compounds that form nucleosides, which, in turn, are components of nucleotides, with all of these monomers constituting the basic building blocks of nuc ...
adenine
Adenine (, ) (nucleoside#List of nucleosides and corresponding nucleobases, symbol A or Ade) is a purine nucleotide base that is found in DNA, RNA, and Adenosine triphosphate, ATP. Usually a white crystalline subtance. The shape of adenine is ...
(a key component of nucleic acids
Nucleic acids are large biomolecules that are crucial in all cells and viruses. They are composed of nucleotides, which are the monomer components: a 5-carbon sugar, a phosphate group and a nitrogenous base. The two main classes of nucleic a ...
) from hydrogen cyanide
Hydrogen cyanide (formerly known as prussic acid) is a chemical compound with the chemical formula, formula HCN and structural formula . It is a highly toxic and flammable liquid that boiling, boils slightly above room temperature, at . HCN is ...
(HCN). He also showed that amino acids
Amino acids are organic compounds that contain both amino and carboxylic acid functional groups. Although over 500 amino acids exist in nature, by far the most important are the Proteinogenic amino acid, 22 α-amino acids incorporated into p ...
can be made from HCN plus ammonia
Ammonia is an inorganic chemical compound of nitrogen and hydrogen with the chemical formula, formula . A Binary compounds of hydrogen, stable binary hydride and the simplest pnictogen hydride, ammonia is a colourless gas with a distinctive pu ...
in an aqueous solution
An aqueous solution is a solution in which the solvent is water. It is mostly shown in chemical equations by appending (aq) to the relevant chemical formula. For example, a solution of table salt, also known as sodium chloride (NaCl), in water ...
. This was achieved during the period 1959–1962 and stands, together with the Miller-Urey experiment, as one of the fundamental results of prebiotic chemistry. It opened up a research area eventually leading to the complete synthesis of other components of nucleic acids.
Cometary origin of prebiotic molecules
Oró was also the first scientist pointing towards comets
A comet is an icy, small Solar System body that warms and begins to release gases when passing close to the Sun, a process called outgassing. This produces an extended, gravitationally unbound atmosphere or coma surrounding the nucleus, an ...
as key carriers of organic molecules to our early biosphere
The biosphere (), also called the ecosphere (), is the worldwide sum of all ecosystems. It can also be termed the zone of life on the Earth. The biosphere (which is technically a spherical shell) is virtually a closed system with regard to mat ...
. This conjecture (formulated in 1961) is broadly accepted today. Although such an idea had been around for a long time, it was only when both space exploration and prebiotic chemistry fully developed that extensive evidence was in place. Comets are rich in carbon and water, bearing along precursor molecules based on carbon chemistry, such as amino acids. In this context, in 1971, Oró and co-workers published a paper revealing the high abundance of amino acids, aliphatic and aromatic hydrocarbons in the Murchison meteorite
The Murchison meteorite is a meteorite that fell in Australia in 1969 near Murchison, Victoria. It belongs to the carbonaceous chondrite class, a group of meteorites rich in organic compounds. Due to its mass (over ) and the fact that it was ...
and studied the optical activity of the amino acids.
Viking mission
Oró also provided a chemical interpretation of a set of remarkable, and to some extent unexpected results reported by the Viking mission to Mars. The Viking lander performed a series of experiments, including one designed by Oró, involving a small gas chromatograph and mass spectrometer
Mass spectrometry (MS) is an analytical technique that is used to measure the mass-to-charge ratio of ions. The results are presented as a '' mass spectrum'', a plot of intensity as a function of the mass-to-charge ratio. Mass spectrometry is us ...
. In one of these experiments, where a set of nutrients was mixed with Martian soil samples, a sudden production of carbon dioxide was reported, initially suggesting the presence of Martian microbes, which would have shown some kind of metabolic processing of nutrients. Oró showed that a simpler, abiotic interpretation was more likely to be the correct one: the catalytic chemical oxidation of test nutrients.[
]
Other activities
Oró was also involved in political life after Spain's transition to democracy as member of the Parliament of Catalonia
The Parliament of Catalonia (, ; ; ) is the Unicameralism, unicameral legislature of the Autonomous communities of Spain, autonomous community of Catalonia. The Parliament is currently made up of 135 members, known as Deputy (legislator), deput ...
.
He also served as a science advisor for many American projects and committees, including those involved in the International Space Station
The International Space Station (ISS) is a large space station that was Assembly of the International Space Station, assembled and is maintained in low Earth orbit by a collaboration of five space agencies and their contractors: NASA (United ...
and the future missions to Mars.
Awards and honors
*1983: Cross of Civil Order of Alfonso X el Sabio (Madrid
Madrid ( ; ) is the capital and List of largest cities in Spain, most populous municipality of Spain. It has almost 3.5 million inhabitants and a Madrid metropolitan area, metropolitan area population of approximately 7 million. It i ...
)
*1986: Oparin Medal from the International Society for the Study of the Origin of Life (ISSOL) ( Berkeley),
*1991: Creu de Sant Jordi
*2000: Medalla del President Francesc Macià
*2003: Named "Marquess of Oró" in 2003 by Royal Decree 819-32003 of 23 June.
*2024: Premio In Memoriam (Posthumous Award) in the Premios Vanguardia in Barcelona
Personal life and death
Oró married Francesca Forteza in 1948, and they had four children, the first three born in Spain and the youngest born in Houston.[
Oró died in Barcelona on September 2, 2004.]
References
External links
Joan Oró Foundation
, -
{{DEFAULTSORT:Oro, Joan
1923 births
2004 deaths
Scientists from Catalonia
Spanish biochemists
People from Lleida
Astrobiologists