William James Kent (born February 10, 1960) is an American
research scientist
A scientist is a person who researches to advance knowledge in an area of the natural sciences.
In classical antiquity, there was no real ancient analog of a modern scientist. Instead, philosophers engaged in the philosophical study of nature ...
and
computer programmer
A programmer, computer programmer or coder is an author of computer source code someone with skill in computer programming.
The professional titles ''software developer'' and ''software engineer'' are used for jobs that require a progr ...
. He has been a contributor to
genome
A genome is all the genetic information of an organism. It consists of nucleotide sequences of DNA (or RNA in RNA viruses). The nuclear genome includes protein-coding genes and non-coding genes, other functional regions of the genome such as ...
database projects and the 2003 winner of the
Benjamin Franklin Award.
Early life
Kent was born in
Hawaii
Hawaii ( ; ) is an island U.S. state, state of the United States, in the Pacific Ocean about southwest of the U.S. mainland. One of the two Non-contiguous United States, non-contiguous U.S. states (along with Alaska), it is the only sta ...
and grew up in
San Francisco, California
San Francisco, officially the City and County of San Francisco, is a commercial, Financial District, San Francisco, financial, and Culture of San Francisco, cultural center of Northern California. With a population of 827,526 residents as of ...
,
United States
The United States of America (USA), also known as the United States (U.S.) or America, is a country primarily located in North America. It is a federal republic of 50 U.S. state, states and a federal capital district, Washington, D.C. The 48 ...
.
Computer animation
Kent began his programming career in 1983 with Island Graphics Inc. where he wrote the Aegis Animator program for the
Amiga
Amiga is a family of personal computers produced by Commodore International, Commodore from 1985 until the company's bankruptcy in 1994, with production by others afterward. The original model is one of a number of mid-1980s computers with 16-b ...
home computer. This program combined polygon tweening in 3D with simple 2D cel-based animation. In 1985 he founded and ran a software company, Dancing Flame, which adapted the Aegis Animator to the
Atari ST
Atari ST is a line of personal computers from Atari Corporation and the successor to the company's Atari 8-bit computers, 8-bit computers. The initial model, the Atari 520ST, had limited release in April–June 1985, and was widely available i ...
, and created Cyber Paint for that machine. Cyber Paint was a 2D animation program that brought together a wide variety of animation and paint functionality and the delta-compressed animation format developed for CAD-3D. The user could move freely between animation frames and paint arbitrarily, or utilize various animation tools for automatic tweening movement across frames. Cyber Paint was one of the first, if not the first, consumer program that enabled the user to paint across time in a compressed digital video format. Later he developed a similar program, the
Autodesk Animator for
PC compatibles, where the image compression improved to the point it could play off of hard disk, and one could paint using "inks" that performed algorithmic transformations such as smoothing, transparency, and tiled patterns. The Autodesk Animator was used to create artwork for a wide variety of video games.
Involvement with the Human Genome Project
In 2000, he wrote a program, GigAssembler,
that allowed the publicly funded
Human Genome Project
The Human Genome Project (HGP) was an international scientific research project with the goal of determining the base pairs that make up human DNA, and of identifying, mapping and sequencing all of the genes of the human genome from both a ...
to assemble and publish the first human genome sequence. His efforts were motivated by the research needs of himself and his colleagues, but also out of concern that the data might be made proprietary via patents by
Celera Genomics. In their close race with Celera, Kent and the UCSC Professor
David Haussler
David Haussler (born 1953) is an American bioinformatician known for his work leading the team that assembled the first human genome sequence in the race to complete the Human Genome Project and subsequently for comparative genome analysis that d ...
quickly built a modest cluster of 50 commodity
personal computer
A personal computer, commonly referred to as PC or computer, is a computer designed for individual use. It is typically used for tasks such as Word processor, word processing, web browser, internet browsing, email, multimedia playback, and PC ...
s running a
Linux-based operating system
A Linux distribution, often abbreviated as distro, is an operating system that includes the Linux kernel for its kernel functionality. Although the name does not imply product distribution per se, a distro—if distributed on its own—is ofte ...
to run the software. In contrast, Celera was using what was thought then to be one of the most powerful civilian supercomputers in the world. Kent's first assembly on the human genome was released on June 22. Celera finished its assembly three days later on June 25, and the dual results were announced at the
White House
The White House is the official residence and workplace of the president of the United States. Located at 1600 Pennsylvania Avenue Northwest (Washington, D.C.), NW in Washington, D.C., it has served as the residence of every U.S. president ...
on June 26. On July 7, 2000, the Santa Cruz data was made publicly available on the World Wide Web while the research paper describing this publicly funded genome was published in February 2001 special issue of ''
Nature
Nature is an inherent character or constitution, particularly of the Ecosphere (planetary), ecosphere or the universe as a whole. In this general sense nature refers to the Scientific law, laws, elements and phenomenon, phenomena of the physic ...
'',
in parallel with Celera's results in the journal ''
Science
Science is a systematic discipline that builds and organises knowledge in the form of testable hypotheses and predictions about the universe. Modern science is typically divided into twoor threemajor branches: the natural sciences, which stu ...
''.
In 2002
Tim O'Reilly
Timothy O'Reilly (born 6 June 1954) is an Irish-American author and publisher, who is the founder of O'Reilly Media (formerly O'Reilly & Associates). He popularised the terms open source and Web 2.0.
Education and early life
Born in County Co ...
described Kent's work as "the most significant work of open source development in the past year". While all of Kent's genomics software is
open source
Open source is source code that is made freely available for possible modification and redistribution. Products include permission to use and view the source code, design documents, or content of the product. The open source model is a decentrali ...
in the sense that the
source code
In computing, source code, or simply code or source, is a plain text computer program written in a programming language. A programmer writes the human readable source code to control the behavior of a computer.
Since a computer, at base, only ...
can be downloaded and read for free, and all of the software can be freely used for academic, nonprofit, and personal use, some of it requires a
license
A license (American English) or licence (Commonwealth English) is an official permission or permit to do, use, or own something (as well as the document of that permission or permit).
A license is granted by a party (licensor) to another part ...
, either from UCSC or from Kent Informatics Inc., for commercial use.
After GigAssembler, Kent went on to write
BLAT (BLAST-like alignment tool)
and the UCSC Genome Browser
to help analyze important genome data. Kent continues to work at UCSC primarily on web tools to help understand the human genome. He helps maintain and upgrade the browser, and has worked on
comparative genomics
Comparative genomics is a branch of biological research that examines genome sequences across a spectrum of species, spanning from humans and mice to a diverse array of organisms from bacteria to chimpanzees. This large-scale holistic approach c ...
,
Parasol, a job control management software for the UCSC kilocluster, and the
ENCODE
The Encyclopedia of DNA Elements (ENCODE) is a public research project which aims "to build a comprehensive parts list of functional elements in the human genome."
ENCODE also supports further biomedical research by "generating community resourc ...
Project.
References
External links
O'Reilly Interview with Jim KentWired article on Jim Kent
{{DEFAULTSORT:Kent, Jim
1960 births
Living people
American bioinformaticians
21st-century American biologists
American computer programmers
University of California, Santa Cruz alumni
University of California, Santa Cruz faculty
People in the computer animation industry
Overton Prize winners
Human Genome Project scientists
Biologists from Hawaii