Jeryl Lynn are strains of mumps virus used in the

Mumpsvax Mumps vaccines are vaccines which prevent mumps. When given to a majority of the population they decrease complications at the population level. Effectiveness when 90% of a population is vaccinated is estimated at 85%. Two doses are required fo ...

mumps MUMPS ("Massachusetts General Hospital Utility Multi-Programming System"), or M, is an imperative, high-level programming language with an integrated transaction processing key–value database. It was originally developed at Massachusetts Gen ...

vaccine A vaccine is a biological preparation that provides active acquired immunity to a particular infectious or malignant disease. The safety and effectiveness of vaccines has been widely studied and verified. ...

made by

Merck Merck refers primarily to the German Merck family and three companies founded by the family, including: * the Merck Group, a German chemical, pharmaceutical and life sciences company founded in 1668 ** Merck Serono (known as EMD Serono in the Unite ...

. The strains are named after Jeryl Lynn Hilleman. In 1963, Jeryl's father,

Maurice Hilleman Maurice Ralph Hilleman (August 30, 1919 – April 11, 2005) was a leading American microbiologist who specialized in vaccinology and developed over 40 vaccines, an unparalleled record of productivity. According to one estimate, his vaccines ...

, was leading efforts to produce a

mumps vaccine Mumps vaccines are vaccines which prevent mumps. When given to a majority of the population they decrease complications at the population level. Effectiveness when 90% of a population is vaccinated is estimated at 85%. Two doses are required fo ...

for Merck. He cultured the mumps virus from her throat, and in 1967 a vaccine was produced which is now widely used. The Jeryl Lynn strains used in the manufacture of Mumpsvax later turned out to contain two distinguishable viral substrains, ''JL1'' and ''JL2''. Further research showed that the JL1 strain was preferentially selected by propagation in Vero and chick embryo fibroblast (CEF)

cell cultures Cell culture or tissue culture is the process by which cells are grown under controlled conditions, generally outside of their natural environment. The term "tissue culture" was coined by American pathologist Montrose Thomas Burrows. This te ...

. The JL2 strain was preferentially selected by passage in embryonated chicken eggs. In the US, the Jeryl Lynn strain-based vaccines supplanted the previous, killed virus, vaccine in 1978.

References

{{vaccines Vaccines Mumps

See also

References