Jay O'Brien may refer to:
*
Jay O'Brien (ice hockey)
Jay O'Brien (born November 4, 1999) is an American professional ice hockey center who is currently an unrestricted free agent. He was most recently under contract with the Charlotte Checkers of the American Hockey League (AHL). He was drafted in ...
*
Jay O'Brien (bobsleigh)
Jay James O'Brien (February 22, 1883 – April 5, 1940) was an American bobsledder who competed in the late 1920s and early 1930s. He won two medals at the Winter Olympics with a gold in the four-man event at Lake Placid, New York, in 1932 a ...
*
Jay O'Brien (Virginia politician)
{{hndis, Obrien, Jay