Jason S. Lewis is a British radiochemist whose work relates to oncologic therapy and

diagnosis Diagnosis is the identification of the nature and cause of a certain phenomenon. Diagnosis is used in many different disciplines, with variations in the use of logic, analytics, and experience, to determine " cause and effect". In systems engin ...

. His research focus is a molecular imaging-based program focused on

radiopharmaceutical Radiopharmaceuticals, or medicinal radiocompounds, are a group of pharmaceutical drugs containing radioactive isotopes. Radiopharmaceuticals can be used as diagnostic and therapeutic agents. Radiopharmaceuticals emit radiation themselves, which is ...

development as well as the study of multimodality (

PET A pet, or companion animal, is an animal kept primarily for a person's company or entertainment rather than as a working animal, livestock, or a laboratory animal. Popular pets are often considered to have attractive appearances, intelligence ...

, CT &

MRI Magnetic resonance imaging (MRI) is a medical imaging technique used in radiology to form pictures of the anatomy and the physiological processes inside the body. MRI scanners use strong magnetic fields, magnetic field gradients, and radio w ...

) small- and

biomolecule A biomolecule or biological molecule is a loosely used term for molecules present in organisms that are essential to one or more typically biological processes, such as cell division, morphogenesis, or development. Biomolecules include larg ...

-based agents and their clinical translation. He has worked on the development of small

molecule A molecule is a group of two or more atoms held together by attractive forces known as chemical bonds; depending on context, the term may or may not include ions which satisfy this criterion. In quantum physics, organic chemistry, and bio ...

s as well as radiolabeled peptides and antibodies probing the overexpression of receptors and

antigen In immunology, an antigen (Ag) is a molecule or molecular structure or any foreign particulate matter or a pollen grain that can bind to a specific antibody or T-cell receptor. The presence of antigens in the body may trigger an immune response. ...

s on

tumors A neoplasm () is a type of abnormal and excessive growth of tissue. The process that occurs to form or produce a neoplasm is called neoplasia. The growth of a neoplasm is uncoordinated with that of the normal surrounding tissue, and persists ...

Education

Jason S. Lewis was born and raised in Horndean, Hampshire, England. Lewis received his Bachelor of Science in chemistry, B.Sc. from the

University of Essex The University of Essex is a public research university in Essex, England. Established by royal charter in 1965, Essex is one of the original plate glass universities. Essex's shield consists of the ancient arms attributed to the Kingdom of Es ...

in 1992. He received his Master of Science in chemistry from the University of Essex in 1993. In 1996, he received his

Doctor of Philosophy A Doctor of Philosophy (PhD, Ph.D., or DPhil; Latin: or ') is the most common degree at the highest academic level awarded following a course of study. PhDs are awarded for programs across the whole breadth of academic fields. Because it is ...

Biochemistry Biochemistry or biological chemistry is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology ...

at the

University of Kent , motto_lang = , mottoeng = Literal translation: 'Whom to serve is to reign'(Book of Common Prayer translation: 'whose service is perfect freedom')Graham Martin, ''From Vision to Reality: the Making of the University of Kent at Canterbury'' ...

Career

Lewis was an instructor of

Radiology Radiology ( ) is the medical discipline that uses medical imaging to diagnose diseases and guide their treatment, within the bodies of humans and other animals. It began with radiography (which is why its name has a root referring to radiati ...

at the Washington University School of Medicine,

Mallinckrodt Institute of Radiology The Mallinckrodt Institute of Radiology (MIR), established 1931, is an academic radiology center associated with the Washington University School of Medicine, located within the Washington University Medical Center in St. Louis, Missouri. In additi ...

from 2000 to 2002. From 2003 to 2008, he was an assistant professor of radiology at the Washington University School of Medicine, Mallinckrodt Institute of Radiology. He is the Emily Tow Jackson Chair in Oncology, the Vice Chairman for Research (Radiology) and Chief Attending of the Radiochemistry and Imaging Sciences Service at Memorial Sloan Kettering Cancer Center. He also heads a laboratory in the Sloan Kettering Institute's Molecular Pharmacology Program and is a professor at the Gerstner Sloan Kettering Graduate School of Biomedical Sciences. Lewis holds joint appointments in the Departments of Radiology and the Department of Pharmacology at Weill Cornell Medical School, NY.

Research focus

Lewis is a proponent of development imaging tools for use in

personalized medicine Personalized medicine, also referred to as precision medicine, is a medical model that separates people into different groups—with medical decisions, practices, interventions and/or products being tailored to the individual patient based on the ...

. Lewis designs and develops radiochemical probes for use in

nuclear medicine Nuclear medicine or nucleology is a medical specialty involving the application of radioactive substances in the diagnosis and treatment of disease. Nuclear imaging, in a sense, is "radiology done inside out" because it records radiation emit ...

as well as multi-modality molecular imaging. The use of these probes span from oncological metabolic detection to understanding the biological processes of

cancer Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal bl ...

and pharmacological modification. These probes can be used for

biomarker In biomedical contexts, a biomarker, or biological marker, is a measurable indicator of some biological state or condition. Biomarkers are often measured and evaluated using blood, urine, or soft tissues to examine normal biological processes, p ...

s in clinical trials as well as used as an agent for oncological diagnostics. He has developed multiple new small molecules that target tumor metabolism, as well as radiolabeled peptides and antibodies for use in probing overexpression of receptors and antigens on tumors for research, clinical trials and in the clinic.

Recognition

*2014 Distinguished Investigator Award from the Academy of Radiology Research *Fellow, World Molecular Imaging Society (FWMIS) * 2017 Michael J. Welch Award, Society of Nuclear Medicine and Molecular Imaging (SNMMI) * 2019 Paul C. Aebersold Award, Educational and Research Fund for Nuclear Medicine and Molecular Imaging (ERF) &

Society of Nuclear Medicine and Molecular Imaging The Society of Nuclear Medicine and Molecular Imaging (SNMMI), formerly the Society of Nuclear Medicine, is a nonprofit scientific and professional organization that promotes the science, technology and practical application of nuclear medicine ...

* 2019 Fellow,

(FSNMMI)

Editorial board memberships

* Molecular Imaging and Biology (Editor-in-Chief) *

Journal of Nuclear Medicine ''The Journal of Nuclear Medicine'' is a monthly peer-reviewed medical journal published by Society of Nuclear Medicine and Molecular Imaging that covers research on all aspects of nuclear medicine, including molecular imaging. Abstracting and in ...

(Associate Editor) * ACS Bioconjugate Chemistry (Editorial Advisory Board) *

Nuclear Medicine and Biology ''Nuclear Medicine and Biology'' is a peer-reviewed medical journal published by Elsevier that covers research on all aspects of nuclear medicine, including radiopharmacology, radiopharmacy and clinical studies of targeted radiotracers. It is the ...

(Associate Editor-in-Chief)

References

{{DEFAULTSORT:Lewis, Jason S. 1970 births Alumni of the University of Kent Alumni of the University of Essex Living people Radiochemistry Washington University School of Medicine faculty Weill Medical College of Cornell University faculty