Jane Anne Russell (also called Jane Anne Russell Wilhelmi; February 9, 1911 – March 12, 1967) was an

endocrinologist Endocrinology (from ''endocrine'' + '' -ology'') is a branch of biology and medicine dealing with the endocrine system, its diseases, and its specific secretions known as hormones. It is also concerned with the integration of developmental events ...

. She researched

pituitary The pituitary gland or hypophysis is an endocrine gland in vertebrates. In humans, the pituitary gland is located at the base of the brain, protruding off the bottom of the hypothalamus. The pituitary gland and the hypothalamus control much of th ...

extract.

Education

Russell graduated from

Long Beach Polytechnic High School Long Beach Polytechnic High School, founded in 1895 as Long Beach High School, is a four-year public high school located at 1600 Atlantic Avenue in Long Beach, California, United States. The school serves portions of Long Beach, including Bixby ...

California California () is a U.S. state, state in the Western United States that lies on the West Coast of the United States, Pacific Coast. It borders Oregon to the north, Nevada and Arizona to the east, and shares Mexico–United States border, an ...

, in 1928, as the second best student in her class. At age 17, she entered the

University of California Berkeley The University of California, Berkeley (UC Berkeley, Berkeley, Cal, or California), is a public land-grant research university in Berkeley, California, United States. Founded in 1868 and named after the Anglo-Irish philosopher George Berkeley ...

, and graduated in 1932 as first in her class. She was awarded the California Fellowship in

Biochemistry Biochemistry, or biological chemistry, is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology, a ...

in 1934 and the Rosenberg Fellowship in 1935. Russell obtained her

PhD A Doctor of Philosophy (PhD, DPhil; or ) is a terminal degree that usually denotes the highest level of academic achievement in a given discipline and is awarded following a course of graduate study and original research. The name of the deg ...

in 1937 working at the Institute of Experimental Biology at the University of California, Berkeley on the study of

pituitary hormones The pituitary gland or hypophysis is an endocrine gland in vertebrates. In humans, the pituitary gland is located at the base of the brain, protruding off the bottom of the hypothalamus. The pituitary gland and the hypothalamus control much of th ...

carbohydrate metabolism Carbohydrate metabolism is the whole of the biochemistry, biochemical processes responsible for the metabolic anabolism, formation, catabolism, breakdown, and interconversion of carbohydrates in life, living organisms. Carbohydrates are central t ...

Career

Following her Ph.D., she continued at the University of California, Berkeley doing post-doctoral research on a Porter fellowship from the

American Physiological Society The American Physiological Society is a non-profit professional society for physiologists. It has nearly 10,000 members, most of whom hold doctoral degrees in medicine, physiology, or other health professions. Its mission is to support research ...

. In 1938 she moved to

Yale University Yale University is a Private university, private Ivy League research university in New Haven, Connecticut, United States. Founded in 1701, Yale is the List of Colonial Colleges, third-oldest institution of higher education in the United Stat ...

, where she first worked as a postdoctoral investigator and was an instructor from 1941 until 1950 when she moved to

Emory University Emory University is a private university, private research university in Atlanta, Georgia, United States. It was founded in 1836 as Emory College by the Methodist Episcopal Church and named in honor of Methodist bishop John Emory. Its main campu ...

. She taught biochemistry at Emory University from 1950 to 1967. During 1954–57 Russell worked on the committee of the

United States National Research Council The National Academies of Sciences, Engineering, and Medicine (NASEM), also known as the National Academies, is a congressionally chartered organization that serves as the collective scientific national academy of the United States. The name i ...

, then during 1958–64 at the

National Science Foundation The U.S. National Science Foundation (NSF) is an Independent agencies of the United States government#Examples of independent agencies, independent agency of the Federal government of the United States, United States federal government that su ...

. She became a full professor at Emory University in 1965.

Research

In 1936, Russell spent time working with the Nobel-prize winning couple

Carl Ferdinand Cori Carl Ferdinand Cori, ForMemRS (December 5, 1896 – October 20, 1984) was a Czech-American biochemist and pharmacologist. He, together with his wife Gerty Cori and Argentine physiologist Bernardo Houssay, received a Nobel Prize in 1947 for th ...

and

Gerty Cori Gerty Theresa Cori (; August 15, 1896 – October 26, 1957) was a Bohemian-Austrian and American biochemist who in 1947 was the third woman to win a Nobel Prize in science, and the first woman to be awarded the Nobel Prize in Physiology or Me ...

researching the impact of epinephrine and insulin on metabolism.

Pituitary gland research

Russell's major research indicated that fasting rats lose muscle

glycogen Glycogen is a multibranched polysaccharide of glucose that serves as a form of energy storage in animals, fungi, and bacteria. It is the main storage form of glucose in the human body. Glycogen functions as one of three regularly used forms ...

following

removal and injections of pituitary extract can prevent weight loss. She determined the relationship between the

anterior pituitary The anterior pituitary (also called the adenohypophysis or pars anterior) is a major Organ (anatomy), organ of the endocrine system. The anterior pituitary is the glandular, Anatomical terms of location#Usage in human anatomy, anterior lobe that t ...

and

carbohydrates A carbohydrate () is a biomolecule composed of carbon (C), hydrogen (H), and oxygen (O) atoms. The typical hydrogen-to-oxygen atomic ratio is 2:1, analogous to that of water, and is represented by the empirical formula (where ''m'' and ''n'' ma ...

. Her work allowed the further isolation and identification of

growth hormones Growth hormone (GH) or somatotropin, also known as human growth hormone (hGH or HGH) in its human form, is a peptide hormone that stimulates growth, cell reproduction, and cell regeneration in humans and other animals. It is thus important in ...

Recognition

Russell was awarded the Kraft Prize, Phi Beta Kappa Key, Steward Scholarship, and University Gold Medal. In 1945 she received the CIBA award of the

Endocrine Society The Endocrine Society is a professional, international medical organization in the field of endocrinology and metabolism, founded in 1916 as The Association for the Study of Internal Secretions. The official name of the organization was changed t ...

. She worked on the

National Institutes of Health The National Institutes of Health (NIH) is the primary agency of the United States government responsible for biomedical and public health research. It was founded in 1887 and is part of the United States Department of Health and Human Service ...

peer review committee, and was Vice President of the Endocrine Society. Russell was awarded the Upjohn Award of the Endocrine Society in 1961 and elected a member of

Sigma Xi Sigma Xi, The Scientific Research Honor Society () is an international non-profit honor society for scientists and engineers. Sigma Xi was founded at Cornell University by a faculty member and graduate students in 1886 and is one of the oldest ...

Personal life

Russell married Alfred Ellis Wilhelmi in 1940. She enjoyed gardening, sewing and

origami ) is the Japanese art of paper folding. In modern usage, the word "origami" is often used as an inclusive term for all folding practices, regardless of their culture of origin. The goal is to transform a flat square sheet of paper into a ...

. Russell developed

breast cancer Breast cancer is a cancer that develops from breast tissue. Signs of breast cancer may include a Breast lump, lump in the breast, a change in breast shape, dimpling of the skin, Milk-rejection sign, milk rejection, fluid coming from the nipp ...

in 1962, but worked to the end of her life.

References

{{DEFAULTSORT:Russell, Jane Anne 1911 births 1967 deaths American endocrinologists American women endocrinologists University of California, Berkeley alumni 20th-century American physicians Emory University faculty American women biochemists 20th-century American women scientists Long Beach Polytechnic High School alumni 20th-century American biochemists