James Ruffin may refer to:
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James E. Ruffin
James Edward Ruffin (July 24, 1893 – April 9, 1977) was a U.S. Representative from Missouri.
Born on a farm near Covington, Tennessee, Ruffin moved to Aurora, Missouri with his parents.
He graduated from Aurora High School in 1912 and fro ...
(1893–1977), US representative from Missouri
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James Ruffin (American football) (born 1987), American football defensive end
{{Hndis, Ruffin, James