James Bertram Collip (November 20, 1892 – June 19, 1965) was a Canadian biochemist who was part of the

Toronto Toronto ( , locally pronounced or ) is the List of the largest municipalities in Canada by population, most populous city in Canada. It is the capital city of the Provinces and territories of Canada, Canadian province of Ontario. With a p ...

group which isolated

insulin Insulin (, from Latin ''insula'', 'island') is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the insulin (''INS)'' gene. It is the main Anabolism, anabolic hormone of the body. It regulates the metabol ...

. He served as the chair of the department of biochemistry at

McGill University McGill University (French: Université McGill) is an English-language public research university in Montreal, Quebec, Canada. Founded in 1821 by royal charter,Frost, Stanley Brice. ''McGill University, Vol. I. For the Advancement of Learning, ...

from 1928 to 1941 and dean of medicine at the

University of Western Ontario The University of Western Ontario (UWO; branded as Western University) is a Public university, public research university in London, Ontario, Canada. The main campus is located on of land, surrounded by residential neighbourhoods and the Thame ...

from 1947 to 1961, where he was a charter member of The

Kappa Alpha Society The Kappa Alpha Society () is a North American social college fraternity. Founded in 1825, it was the progenitor of the modern fraternity system in North America. It is considered to be the oldest national, secret, Greek-letter social fraterni ...

Education

Born in

Belleville, Ontario Belleville is a city in Ontario, Canada, situated on the eastern end of Lake Ontario, located at the mouth of the Moira River and on the Bay of Quinte. Its population as of the 2021 Canadian census was 55,071 (Census Metropolitan Area population 1 ...

, he enrolled at Trinity College at the

University of Toronto The University of Toronto (UToronto or U of T) is a public university, public research university whose main campus is located on the grounds that surround Queen's Park (Toronto), Queen's Park in Toronto, Ontario, Canada. It was founded by ...

at the age of 15, and studied

physiology Physiology (; ) is the science, scientific study of function (biology), functions and mechanism (biology), mechanisms in a life, living system. As a branches of science, subdiscipline of biology, physiology focuses on how organisms, organ syst ...

and

biochemistry Biochemistry, or biological chemistry, is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology, a ...

. He obtained a Ph.D. in biochemistry from the same university in 1916.

Career

In 1915, at the age of 22, Collip accepted a lecturing position in

Edmonton Edmonton is the capital city of the Provinces and territories of Canada, Canadian province of Alberta. It is situated on the North Saskatchewan River and is the centre of the Edmonton Metropolitan Region, which is surrounded by Central Alberta ...

in the department of physiology at the

University of Alberta The University of Alberta (also known as U of A or UAlberta, ) is a public research university located in Edmonton, Alberta, Canada. It was founded in 1908 by Alexander Cameron Rutherford, the first premier of Alberta, and Henry Marshall Tory, t ...

Faculty of Medicine, shortly before completing his doctorate. He fulfilled the role for 7 years, eventually rising to the position of professor and head of the department of biochemistry in 1922. His research at the time was mainly focused on

blood Blood is a body fluid in the circulatory system of humans and other vertebrates that delivers necessary substances such as nutrients and oxygen to the cells, and transports metabolic waste products away from those same cells. Blood is com ...

chemistry Chemistry is the scientific study of the properties and behavior of matter. It is a physical science within the natural sciences that studies the chemical elements that make up matter and chemical compound, compounds made of atoms, molecules a ...

vertebrates Vertebrates () are animals with a vertebral column (backbone or spine), and a cranium, or skull. The vertebral column surrounds and protects the spinal cord, while the cranium protects the brain. The vertebrates make up the subphylum Vertebra ...

and

invertebrates Invertebrates are animals that neither develop nor retain a vertebral column (commonly known as a ''spine'' or ''backbone''), which evolved from the notochord. It is a paraphyletic grouping including all animals excluding the chordate subphylum ...

. He took a

sabbatical A sabbatical (from the Hebrew: (i.e., Sabbath); in Latin ; Greek: ) is a rest or break from work; "an extended period of time intentionally spent on something that’s not your routine job." The concept of the sabbatical is based on the Bi ...

leave beginning in April 1921, and travelled to Toronto on a Rockefeller Travelling Scholarship for a six-month position with Professor John MacLeod of the University of Toronto's department of physiology. There his research program (on the effect of pH on the concentration of sugar in the blood) would take him to the

Marine Biological Laboratory The Marine Biological Laboratory (MBL) is an international center for research and education in biological and environmental science. Founded in Woods Hole, Massachusetts, in 1888, the MBL is a private, nonprofit institution that was independent ...

in Woods Hole, Massachusetts, and St. Andrews Biological Station in Saint Andrews, New Brunswick, before he returned to Toronto late in the year.

Success of insulin

MacLeod was overseeing the work of

Frederick Banting Sir Frederick Grant Banting (November 14, 1891 – February 21, 1941) was a Canadian pharmacologist, orthopedist, and field surgeon. For his co-discovery of insulin and its therapeutic potential, Banting was awarded the Nobel Prize in Physi ...

and Charles Best in their search for a treatment for

diabetes Diabetes mellitus, commonly known as diabetes, is a group of common endocrine diseases characterized by sustained high blood sugar levels. Diabetes is due to either the pancreas not producing enough of the hormone insulin, or the cells of th ...

which they had begun in May 1921. In December, when Banting and Best were having difficulties in refining the pancreatic extract, MacLeod freed Collip from his other research to enable him to join the research team. Collip's task was to prepare insulin in a more pure, usable form than Banting and Best had been able to achieve to date. In January 1922, after 14-year-old Leonard Thompson suffered a severe allergic reaction to an injection of insulin, Collip achieved the goal of preparing a pancreatic extract pure enough for Thompson to recover and to use in clinical trials. Despite Collip's breakthrough, Banting was furious as he saw that "Collip's discoveries were not a cause for celebration but a new threat". At some point between January 17 and 24, Collip and Banting reportedly had a physical altercation in the labs, supposedly when "Collip visited Banting and Best in their lab and told them that he wasn’t going to share the latest extract formulation (which may or may not have had Macleod's blessing) and that he was contemplating leaving the research team and patenting the process on his own". A colleague later lampooned this incident with a "cartoon showing Banting sitting on Collip and titled 'The Discovery of Insulin.'" Nonetheless, successful trials were soon completed and the future of insulin was assured. Banting, Best and Collip subsequently shared the patent for insulin, which they sold to the University of Toronto for one dollar. Due to disagreements between Banting and MacLeod, there was ill will generated within the team. The Nobel Prize for Medicine was awarded to Banting and MacLeod in 1923. Feeling that Best had been overlooked in the award, Banting shared his portion with Best. In response, MacLeod shared his portion with Collip. Nonetheless, Collip is often overlooked as a co-discoverer of insulin, in part due to Best's public relations campaign that downplayed Collip's crucial role. Following this early success, Collip returned to Edmonton to take up a position as Head of the new Department of Biochemistry, and to pursue his own studies on hormone research. In 1928 he was recruited to

in Montreal by his former graduate advisor, Archibald Macallum. Collip served as Chair of McGill's Department of Biochemistry from 1928 to 1941. From 1947 to 1961, Collip was appointed Dean of Medicine at the

. He is regarded as a pioneer of endocrine research. He did pioneering work with the

parathyroid hormone Parathyroid hormone (PTH), also called parathormone or parathyrin, is a peptide hormone secreted by the parathyroid glands that regulates serum calcium and phosphate through its actions on the bone, kidneys, and small intestine. PTH incre ...

(PTH). He died on June 19, 1965, at the age of 72.

Honours and awards

* Fellow of the

Royal Society of Canada The Royal Society of Canada (RSC; , SRC), also known as the Academies of Arts, Humanities, and Sciences of Canada (French: ''Académies des arts, des lettres et des sciences du Canada''), is the senior national, bilingual council of distinguishe ...

, 1925 * Fellow of the

Royal Society The Royal Society, formally The Royal Society of London for Improving Natural Knowledge, is a learned society and the United Kingdom's national academy of sciences. The society fulfils a number of roles: promoting science and its benefits, re ...

, 1933 * Honorary Doctorate D.Sc,

Harvard University Harvard University is a Private university, private Ivy League research university in Cambridge, Massachusetts, United States. Founded in 1636 and named for its first benefactor, the History of the Puritans in North America, Puritan clergyma ...

, 1936 *

Cameron Prize for Therapeutics of the University of Edinburgh The Cameron Prize for Therapeutics of the University of Edinburgh is awarded by the University of Edinburgh College of Medicine and Veterinary Medicine, College of Medicine and Veterinary Medicine to a person who has made any highly important and v ...

, 1937 * Commander of the

Order of the British Empire The Most Excellent Order of the British Empire is a British order of chivalry, rewarding valuable service in a wide range of useful activities. It comprises five classes of awards across both civil and military divisions, the most senior two o ...

, 1943 * Honorary Doctorate D.Sc,

University of Oxford The University of Oxford is a collegiate university, collegiate research university in Oxford, England. There is evidence of teaching as early as 1096, making it the oldest university in the English-speaking world and the List of oldest un ...

, 1946 *Honorary Doctorate,

, 1946 * Medal of Freedom with Silver Palm (US), 1947 * Banting Medal of the

American Diabetes Association The American Diabetes Association (ADA) is a United States-based nonprofit that seeks to educate the public about diabetes and to help those affected by it through funding research to manage, cure and prevent diabetes, including type 1 diabetes ...

, 1960 * Honorary Doctorate D.Sc from the

, 30 May 1964

References

External links

The Discovery and Early Development of Insulin digital collection, University of Toronto

Biography of James Bertram Collip
{{DEFAULTSORT:Collip, James 1892 births 1965 deaths Canadian medical researchers Trinity College (Canada) alumni University of Toronto alumni Academic staff of the University of Toronto Academic staff of the University of Alberta Academic staff of the University of Western Ontario Canadian university and college faculty deans Canadian Commanders of the Order of the British Empire Fellows of the Royal Society of Canada People from Belleville, Ontario Canadian fellows of the Royal Society Academic staff of McGill University Fellows of the Royal College of Physicians 20th-century Canadian inventors