Jakub Karol Parnas, also known as Yakov Oskarovich Parnas (; January 16, 1884 – January 29, 1949) was a prominent Polish–

Soviet The Union of Soviet Socialist Republics. (USSR), commonly known as the Soviet Union, was a List of former transcontinental countries#Since 1700, transcontinental country that spanned much of Eurasia from 1922 until Dissolution of the Soviet ...

biochemist Biochemists are scientists who are trained in biochemistry. They study chemical processes and chemical transformations in living organisms. Biochemists study DNA, proteins and Cell (biology), cell parts. The word "biochemist" is a portmanteau of ...

who contributed to the discovery of the Embden–Meyerhof–Parnas pathway, together with

Otto Fritz Meyerhof Otto Fritz Meyerhof (; 12 April 1884 – 6 October 1951) was a German physician and biochemist who won the 1922 Nobel Prize in Physiology and Medicine. Biography Otto Fritz Meyerhof was born in Hannover, at Theaterplatz 16A (now:Rathenaustrasse ...

and Gustav Embden. He became a

activist after the annexation of Western Ukraine in 1939. He was arrested during the Jewish Anti-Fascist Committee affair in 1949 and died in the prison, reportedly of heart attack.

Biography

Parnas was born in 1884 in

Tarnopol Ternopil, known until 1944 mostly as Tarnopol, is a city in western Ukraine, located on the banks of the Seret (river), Seret River. Ternopil is one of the major cities of Western Ukraine and the historical regions of Galicia (Central Europe ...

, at that time part of

Austria-Hungary Austria-Hungary, also referred to as the Austro-Hungarian Empire, the Dual Monarchy or the Habsburg Monarchy, was a multi-national constitutional monarchy in Central Europe#Before World War I, Central Europe between 1867 and 1918. A military ...

, in the province of Galicia (now split between Poland and Ukraine), to Jewish parents. He graduated from the Königlich Technische Hochschule Charlottenburg in 1904. From 1920 to 1941, he was head of the Institute of the Medical Chemistry at Lviv University. He traveled across Europe, collaborating with universities in

Cambridge Cambridge ( ) is a List of cities in the United Kingdom, city and non-metropolitan district in the county of Cambridgeshire, England. It is the county town of Cambridgeshire and is located on the River Cam, north of London. As of the 2021 Unit ...

Naples Naples ( ; ; ) is the Regions of Italy, regional capital of Campania and the third-largest city of Italy, after Rome and Milan, with a population of 908,082 within the city's administrative limits as of 2025, while its Metropolitan City of N ...

Strasbourg Strasbourg ( , ; ; ) is the Prefectures in France, prefecture and largest city of the Grand Est Regions of France, region of Geography of France, eastern France, in the historic region of Alsace. It is the prefecture of the Bas-Rhin Departmen ...

Ghent Ghent ( ; ; historically known as ''Gaunt'' in English) is a City status in Belgium, city and a Municipalities of Belgium, municipality in the Flemish Region of Belgium. It is the capital and largest city of the Provinces of Belgium, province ...

and

Zürich Zurich (; ) is the list of cities in Switzerland, largest city in Switzerland and the capital of the canton of Zurich. It is in north-central Switzerland, at the northwestern tip of Lake Zurich. , the municipality had 448,664 inhabitants. The ...

. He was a member of the

German Academy of Sciences Leopoldina The German National Academy of Sciences Leopoldina (), in short Leopoldina, is the national academy of Germany, and is located in Halle (Saale). Founded on 1 January 1652, based on academic models in Italy, it was originally named the ''Academi ...

, Corresponding Member of the

Polish Academy of Sciences The Polish Academy of Sciences (, PAN) is a Polish state-sponsored institution of higher learning. Headquartered in Warsaw, it is responsible for spearheading the development of science across the country by a society of distinguished scholars a ...

, as well an honorary doctor of

Sorbonne University Sorbonne University () is a public research university located in Paris, France. The institution's legacy reaches back to the Middle Ages in 1257 when Sorbonne College was established by Robert de Sorbon as a constituent college of the Unive ...

and the

University of Athens The National and Kapodistrian University of Athens (NKUA; , ''Ethnikó kai Kapodistriakó Panepistímio Athinón''), usually referred to simply as the University of Athens (UoA), is a public university in Athens, Greece, with various campuses alo ...

. After the

Soviet invasion of Poland The Soviet invasion of Poland was a military conflict by the Soviet Union without a formal declaration of war. On 17 September 1939, the Soviet Union invaded Second Polish Republic, Poland from the east, 16 days after Nazi Germany invaded Polan ...

and annexation of

Western Ukraine Western Ukraine or West Ukraine (, ) refers to the western territories of Ukraine. There is no universally accepted definition of the territory's boundaries, but the contemporary Ukrainian administrative regions ( oblasts) of Chernivtsi, I ...

in 1939 by the

Soviet Union The Union of Soviet Socialist Republics. (USSR), commonly known as the Soviet Union, was a List of former transcontinental countries#Since 1700, transcontinental country that spanned much of Eurasia from 1922 until Dissolution of the Soviet ...

, Parnas remained in

Lviv Lviv ( or ; ; ; see #Names and symbols, below for other names) is the largest city in western Ukraine, as well as the List of cities in Ukraine, fifth-largest city in Ukraine, with a population of It serves as the administrative centre of ...

to continue his work in the institute. He also started collaborating with the Soviet authorities by taking on a political role in the communist District

Worker's Delegation. In 1941, after the German invasion of the Soviet Union, Parnas was evacuated deeper into the USSR and remained there for the rest of his life. Only a few days after his departure,

(Lwów) was occupied by the

Nazi Germany Nazi Germany, officially known as the German Reich and later the Greater German Reich, was the German Reich, German state between 1933 and 1945, when Adolf Hitler and the Nazi Party controlled the country, transforming it into a Totalit ...

army, who massacred approximately 45 Lwów professors. Parnas was a member of the

Union of Polish Patriots Union of Polish Patriots (''Society of Polish Patriots'', , ZPP, ) was a political body created by Polish communists in the Soviet Union in 1943. The ZPP, unofficially controlled and directed by Joseph Stalin, became one of the founding structur ...

. In the Soviet Union, Parnas met

Joseph Stalin Joseph Vissarionovich Stalin (born Dzhugashvili; 5 March 1953) was a Soviet politician and revolutionary who led the Soviet Union from 1924 until Death and state funeral of Joseph Stalin, his death in 1953. He held power as General Secret ...

, and received his own laboratory. He became an Academician of the Academy of Sciences of the Soviet Union and a founding member of the USSR Academy of Medical Sciences. Despite his achievements and popularity, Parnas was falsely accused of being a spy of the

West West is one of the four cardinal directions or points of the compass. It is the opposite direction from east and is the direction in which the Sun sets on the Earth. Etymology The word "west" is a Germanic word passed into some Romance langu ...

and arrested by the

KGB The Committee for State Security (, ), abbreviated as KGB (, ; ) was the main security agency of the Soviet Union from 1954 to 1991. It was the direct successor of preceding Soviet secret police agencies including the Cheka, Joint State Polit ...

on January 28, 1949. According to KGB's archives, he died during his first interrogation at Lubyanka prison "from a

heart attack A myocardial infarction (MI), commonly known as a heart attack, occurs when Ischemia, blood flow decreases or stops in one of the coronary arteries of the heart, causing infarction (tissue death) to the heart muscle. The most common symptom ...

" on January 29, 1949.

Achievements

Parnas's major work was the study of the mechanisms of

carbohydrate A carbohydrate () is a biomolecule composed of carbon (C), hydrogen (H), and oxygen (O) atoms. The typical hydrogen-to-oxygen atomic ratio is 2:1, analogous to that of water, and is represented by the empirical formula (where ''m'' and ''n'' ...

metabolism Metabolism (, from ''metabolē'', "change") is the set of life-sustaining chemical reactions in organisms. The three main functions of metabolism are: the conversion of the energy in food to energy available to run cellular processes; the co ...

muscle Muscle is a soft tissue, one of the four basic types of animal tissue. There are three types of muscle tissue in vertebrates: skeletal muscle, cardiac muscle, and smooth muscle. Muscle tissue gives skeletal muscles the ability to muscle contra ...

tissue. Together with Władysław Baranowski, he discovered the process of phosphorolysis. Parnas also made a major contribution to the theoretical analysis of

glycolysis Glycolysis is the metabolic pathway that converts glucose () into pyruvic acid, pyruvate and, in most organisms, occurs in the liquid part of cells (the cytosol). The Thermodynamic free energy, free energy released in this process is used to form ...

. He is the author of about 180 scientific works in German, Polish, English, French, Russian, Ukrainian.

Legacy

Parnas is honored by the Polish–Ukrainian Parnas Conference organized by the Polish and Ukrainian Biochemical Societies, which has been held every two years since 1996.Postepy Biochemii Vol. 43 No. 5 1997 p.311 In 2009, Prof. Andrzej Dżugaj, the President of the Polish Biochemical Society, suggested to include Israeli biochemists to the Conference organizers to acknowledge the roots of J.K. Parnas and his co-workers. Thanks to his efforts, the VIII Parnas Conference took place in 2011, in Poland, for the first time, with the joint organization by three national Societies, Polish, Ukrainian and Israel. In 2013 the conference took place in Jerusalem (organized by Israeli Society for Biochemistry and Molecular Biology). The next Parnas conference took place in Poland at 10–12 July 2016, (Wrocław University).

References

External links

Barańska J ''et al''. (2007) Jakub Karol Parnas – life and creativity (Opening Lecture), 6th Parnas Conference Molecular Mechanism of Cellular Signalling (Kraków, Poland, 30 May – 2 June 2007) ''Acta Biochimica Polonica'' 54 (Suppl. 2), 1
{{DEFAULTSORT:Parnas, Jakob Karol 1884 births 1949 deaths 20th-century biochemists 20th-century Polish chemists People from Ternopil Academic staff of the University of Lviv Academic staff of the University of Warsaw Academicians of the USSR Academy of Medical Sciences Danylo Halytsky Lviv National Medical University alumni Full Members of the USSR Academy of Sciences Technische Universität Berlin alumni Recipients of the Order of Lenin Recipients of the Order of the Red Banner of Labour Recipients of the Stalin Prize Jews from Galicia (Eastern Europe) Jewish scientists Polish people who died in Soviet detention Polish biochemists Soviet biochemists Ukrainian biochemists Jewish Ukrainian scientists ETH Zurich alumni

Biography

Achievements

Legacy

References

Further reading

External links