JAK1 is a human
tyrosine kinase protein essential for signaling for certain type I and type II
cytokines. It interacts with the common gamma chain (γc) of
type I cytokine receptors, to elicit signals from the
IL-2 receptor family (e.g.
IL-2R,
IL-7R,
IL-9R and
IL-15R), the
IL-4 receptor family (e.g.
IL-4R and
IL-13R), the
gp130 receptor family (e.g.
IL-6R,
IL-11R,
LIF-R
LIFR also known as CD118 (Cluster of Differentiation 118), is a subunit of a receptor for leukemia inhibitory factor.
Function
The leukemia inhibitory factor (LIF) is a polyfunctional cytokine that affects the differentiation, survival, ...
,
OSM-R,
cardiotrophin-1
Cardiotrophin-1 (CT-1) is a cytokine. It is a cardiac hypertrophic factor of 21.5 kDa and a protein member of the Interleukin 6, IL-6 cytokine family.
Pathology
CT-1 is associated with the pathophysiology of heart diseases, including hypertens ...
receptor (CT-1R),
ciliary neurotrophic factor receptor (CNTF-R),
neurotrophin-1 receptor (NNT-1R) and
Leptin
Leptin (from Ancient Greek, Greek λεπτός ''leptos'', "thin" or "light" or "small") is a hormone predominantly made by adipose cells and enterocytes in the small intestine that helps to regulate Energy homeostasis, energy balance by inhib ...
-R). It is also important for transducing a signal by type I (IFN-α/β) and type II (IFN-γ)
interferon
Interferons (IFNs, ) are a group of signaling proteins made and released by host cells in response to the presence of several viruses. In a typical scenario, a virus-infected cell will release interferons causing nearby cells to heighten the ...
s, and members of the
IL-10 family via
type II cytokine receptor
Type II cytokine receptors, also commonly known as class II cytokine receptors, are transmembrane proteins that are expressed on the surface of certain cells. They bind and respond to a select group of cytokines including interferon type I, i ...
s.
Jak1 plays a critical role in initiating responses to multiple major cytokine receptor families. Loss of Jak1 is lethal in neonatal mice, possibly due to difficulties suckling.
Expression of JAK1 in cancer cells enables individual cells to contract, potentially allowing them to escape their tumor and
metastasize to other parts of the body.
Interactions
Janus kinase 1 has been shown to
interact with:
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ELP2
Elongator complex protein 2 is a protein that in humans is encoded by the ''ELP2'' gene.
Interactions
ELP2 has been shown to interact with STAT3 and Janus kinase 1.
References
Further reading
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{{gene-18-stub ...
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GNB2L1
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IL6ST
Glycoprotein 130 (also known as gp130, IL6ST, IL6R-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors. It forms one subunit of the type I cytokine receptor within the IL-6 receptor f ...
,
*
Grb2,
*
IL2RB,
STAM2
Signal transducing adapter molecule 2 is a protein that in humans is encoded by the ''STAM2'' gene.
Function
The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine recep ...
,STAT5B
Signal transducer and activator of transcription 5B is a protein that in humans is encoded by the ''STAT5B'' gene. ''STAT5B'' orthologs have been identified in most placentals for which complete genome data are available.
Function
The protein e ...
,[ and
* TNFRSF1A.]
See also
* Janus kinase inhibitor
References
Further reading
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External links
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{{Portal bar, Biology, border=no
Tyrosine kinases