JWH-307 is an

analgesic An analgesic drug, also called simply an analgesic, antalgic, pain reliever, or painkiller, is any member of the group of drugs used for pain management. Analgesics are conceptually distinct from anesthetics, which temporarily reduce, and in s ...

drug used in scientific research, which acts as a

cannabinoid Cannabinoids () are several structural classes of compounds found primarily in the ''Cannabis'' plant or as synthetic compounds. The most notable cannabinoid is the phytocannabinoid tetrahydrocannabinol (THC) (delta-9-THC), the primary psychoact ...

agonist at both the CB₁ and CB₂

receptors Receptor may refer to: *Sensory receptor, in physiology, any neurite structure that, on receiving environmental stimuli, produces an informative nerve impulse *Receptor (biochemistry), in biochemistry, a protein molecule that receives and responds ...

. It is somewhat selective for the CB₂ subtype, with a K_i of 7.7 nM at CB₁ vs 3.3 nM at CB₂. It was discovered by, and named after, John W. Huffman. JWH-307 was detected as an ingredient in

synthetic cannabis Synthetic cannabinoids, or neocannabinoids, are a class of designer drug molecules that bind to the same receptors to which cannabinoids ( THC, CBD and many others) in cannabis plants attach. These novel psychoactive substances should not be co ...

smoking blends in 2012, initially in Germany. In the United States, CB₁ receptor agonists of the 3-(1-naphthoyl)pyrrole class such as JWH-307 are

Schedule I Controlled Substance The Controlled Substances Act (CSA) is the statute establishing federal U.S. drug policy under which the manufacture, importation, possession, use, and distribution of certain substances is regulated. It was passed by the 91st United State ...

References

{{cannabinoid-stub Naphthoylpyrroles JWH cannabinoids 2-Fluorophenyl compounds CB1 receptor agonists CB2 receptor agonists Pentyl compounds

See also

References