J. Bart Classen

John Barthelow Classen is an American immunologist and anti-vaccinationist. He received his M.D. from the University of Maryland, Baltimore in 1988, his M.B.A. from Columbia University in 1992 and obtained his medical license in October 1997. He is best known for publishing research concluding that vaccines, in particular the Hib vaccine, cause insulin-dependent diabetes mellitus, a hypothesis he proposed based on experiments he conducted on mice in 1996. His views are disputed and considered unverified.

A widely-reposted 2021 Facebook post claiming that the mRNA vaccines against COVID-19 could cause prion diseases was based on a paper by Classen. The paper
COVID-19 RNA based vaccines and the risk of prion disease
was published in ''Microbiology and Infectious Diseases'', whose publisher, Scivision Publishers, is included in Beall's list of publishers of predatory journals. Vincent Racaniello, professor of microbiology and immunology at Columbia University, described the claim as "completely wrong". Tulane University virologist Robert Garry stated that Classen has offered no evidence for the three pillars of his argument: that the sequence overlaps between the Pfizer vaccine are greater than occur with any randomly-selected stretch of RNA, or that the vaccine could cause zinc to be released and that doing so would affect its purported targets as he proposes.

Anti-vaccination views

Classen proposes that vaccines cause diabetes by causing the release of interferons, causing an autoimmune state leading to immune-mediated type 1 diabetes, and he is quoted on many anti-vaccine websites, such as that of the National Vaccine Information Center. His work has been criticized, for example, journalist Amy Wallace wrote that the vaccine-diabetes link "...relies on the flawed work of one doctor lassen who gathered data on a slew of vaccines and failed to follow standard study protocols. No other study — including those using the same data — could reproduce the results." Independent studies that have investigated the potential link between vaccines and diabetes include one, published by Frank DeStefano, which "did not find an increased risk of type 1 diabetes associated with any of the routinely recommended childhood vaccines." DeStefano ''et al.'' also noted that another study of over 100,000 children examined the potential connection between Hib vaccines and diabetes and found no association between the two. Similarly, the Australian National Centre for Immunisation Research and Surveillance examined Classen's studies and wrote that "Other researchers who have studied the issue have not verified Dr Classen’s findings."
The American Council on Science and Health has said the following of Classen's claims of a link between vaccines, autism, and immune-related diseases:

Patents

Classen holds a number of patents, specifically regarding "the act of reading the published scientific literature and using it to create vaccination schedules that minimize immune disorders," and has sued four biotechnology companies over allegedly infringing on them. While a district court had found that Classen's idea was too abstract to be patented, an appeals court found otherwise following an appeal by Classen.

Selected publications

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References

{{DEFAULTSORT:Classen, John Barthelow
American anti-vaccination activists
Living people
American immunologists
Year of birth missing (living people)
Columbia Business School alumni
University of Maryland School of Medicine alumni