Ivan Maurice Roitt (born 30 September 1927) is a British scientist. He was educated at

King Edward's School, Birmingham King Edward's School (KES) is an independent school (UK), independent day school for boys in the British Public school (UK), public school tradition, located in Edgbaston, Birmingham. Founded by Edward VI of England, King Edward VI in 1552, it ...

and

Balliol College Balliol College () is a constituent college of the University of Oxford. Founded in 1263 by nobleman John I de Balliol, it has a claim to be the oldest college in Oxford and the English-speaking world. With a governing body of a master and ar ...

Oxford University The University of Oxford is a collegiate research university in Oxford, England. There is evidence of teaching as early as 1096, making it the oldest university in the English-speaking world and the second-oldest continuously operating u ...

. He was Head of the Department of Immunology at

University College London University College London (Trade name, branded as UCL) is a Public university, public research university in London, England. It is a Member institutions of the University of London, member institution of the Federal university, federal Uni ...

from 1967 to 1992, and is currently Honorary Director of the Centre for Investigative & Diagnostic Oncology at

Middlesex University Middlesex University London (legally Middlesex University and abbreviated to MDX) is a public research university based in Hendon, northwest London, England. The university also has campuses in Dubai and Mauritius. The name of the university is ...

, London. In 1956, together with Deborah Doniach and Peter Campbell, he made the classic discovery of

thyroglobulin Thyroglobulin (Tg) is a 660 kDa, dimeric glycoprotein produced by the follicular cells of the thyroid and used entirely within the thyroid gland. Tg is secreted and accumulated at hundreds of grams per litre in the extracellular compartment ...

autoantibodies An autoantibody is an antibody (a type of protein) produced by the immune system that is directed against one or more of the individual's own proteins. Many autoimmune diseases (notably lupus erythematosus) are associated with such antibodies. Pr ...

Hashimoto's thyroiditis Hashimoto's thyroiditis, also known as chronic lymphocytic thyroiditis, Hashimoto's disease and autoimmune thyroiditis, is an autoimmune disease in which the thyroid gland is gradually destroyed. Early on, symptoms may not be noticed. Over ti ...

which helped to open the whole concept of a relationship between

autoimmunity In immunology, autoimmunity is the system of immune responses of an organism against its own healthy cells, tissues and other normal body constituents. Any disease resulting from this type of immune response is termed an " autoimmune disease ...

and human disease. The work was extended to an intensive study of autoimmune phenomena in

pernicious anemia Pernicious anemia is a disease where not enough red blood cells are produced due to a deficiency of Vitamin B12, vitamin B12. Those affected often have a gradual onset. The most common initial symptoms are Fatigue, feeling tired and weak. Other ...

and primary biliary

cirrhosis Cirrhosis, also known as liver cirrhosis or hepatic cirrhosis, chronic liver failure or chronic hepatic failure and end-stage liver disease, is a chronic condition of the liver in which the normal functioning tissue, or parenchyma, is replaced ...

. In 1983 he was elected a Fellow of the

Royal Society The Royal Society, formally The Royal Society of London for Improving Natural Knowledge, is a learned society and the United Kingdom's national academy of sciences. The society fulfils a number of roles: promoting science and its benefits, re ...

, and has been elected to Honorary Membership of the

Royal College of Physicians The Royal College of Physicians of London, commonly referred to simply as the Royal College of Physicians (RCP), is a British professional membership body dedicated to improving the practice of medicine, chiefly through the accreditation of ph ...

and appointed Honorary Fellow of The

Royal Society of Medicine The Royal Society of Medicine (RSM) is a medical society based at 1 Wimpole Street, London, UK. It is a registered charity, with admission through membership. Its Chief Executive is Michele Acton. History The Royal Society of Medicine (R ...

. He was awarded the Gairdner Foundation International Award in 1964. He is an honorary member of the British Society for Immunology.

References

External links

*http://www.roitt.com/ * 1927 births British biochemists Fellows of the Royal Society Living people Alumni of Balliol College, Oxford People educated at King Edward's School, Birmingham Academics of University College London Jewish British scientists {{UK-biochemist-stub