Isotryptamine, also known as 2-(1-indolyl)ethylamine, is a

chemical compound A chemical compound is a chemical substance composed of many identical molecules (or molecular entities) containing atoms from more than one chemical element held together by chemical bonds. A molecule consisting of atoms of only one ele ...

and

positional isomer In chemistry, a structural isomer (or constitutional isomer in the IUPAC nomenclature) of a compound is another compound whose molecule has the same number of atoms of each element, but with logically distinct bonds between them. The term met ...

tryptamine Tryptamine is an indolamine metabolite of the essential amino acid, tryptophan. The chemical structure is defined by an indole ─ a fused benzene and pyrrole ring, and a 2-aminoethyl group at the second carbon (third aromatic atom, with the f ...

(2-(3-indolyl)ethylamine). A variety of isotryptamine

derivative In mathematics, the derivative of a function of a real variable measures the sensitivity to change of the function value (output value) with respect to a change in its argument (input value). Derivatives are a fundamental tool of calculus. ...

s, or

substituted A substitution reaction (also known as single displacement reaction or single substitution reaction) is a chemical reaction during which one functional group in a chemical compound is replaced by another functional group. Substitution reactions ar ...

isotryptamines, have been developed, including

serotonergic psychedelic Psychedelics are a subclass of hallucinogenic drugs whose primary effect is to trigger non-ordinary states of consciousness (known as psychedelic experiences or "trips").Pollan, Michael (2018). ''How to Change Your Mind: What the New Science ...

s and

psychoplastogen Psychoplastogens are a group of small molecule drugs that produce rapid and sustained effects on neuronal structure and function, intended to manifest therapeutic benefit after a single administration. Several existing psychoplastogens have been ...

s like

6-MeO-isoDMT 6-MeO-isoDMT, or 6-OMe-isoDMT, also known as 6-methoxy-''N'',''N''-dimethylisotryptamine, is a serotonin 5-HT2A receptor, 5-HT2A receptor agonist, putative serotonergic psychedelic, and psychoplastogen of the isotryptamine group. It is the isot ...

; non-hallucinogenic psychoplastogens like

isoDMT isoDMT, also known as ''N'',''N''-dimethylisotryptamine, is a putatively non-hallucinogenic serotonin 5-HT2A receptor, 5-HT2A receptor agonist and psychoplastogen of the isotryptamine group. It is the isotryptamine homologue (chemistry), homolo ...

, 5-MeO-isoDMT, and

zalsupindole Zalsupindole,https://iris.who.int/bitstream/handle/10665/380497/9789240107038-eng.pdf "zalsupindolum zalsupindole (2R)-1-(5-methoxy-1H-indol-1-yl)-N,N-dimethylpropan-2-amine antidepressant" also known by its developmental code names DLX-001 and ...

(DLX-001; AAZ-A-154); serotonin 5-HT_2C receptor agonists like (''S'')-5,6-difluoro-isoAMT,

Ro60-0175 Ro60-0175 is a drug developed by Hoffmann–La Roche, which has applications in scientific research. It acts as a potent and selective agonist for both the 5-HT2B and 5-HT2C serotonin receptor subtypes, with good selectivity over the closely ...

((''S'')-5-fluoro-6-chloro-isoAMT), and

PNU-181731 PNU-181731 is a drug which acts as an agonist at serotonin 5-HT2 receptors, with strongest binding affinity for the 5-HT2C subtype at 4.8nM, and weaker 5-HT2A affinity of 18nM. It has anxiolytic effects in animal studies with around one tenth ...

; serotonin 5-HT₆ receptor

modulator In electronics and telecommunications, modulation is the process of varying one or more properties of a periodic waveform, called the ''carrier signal'', with a separate signal called the ''modulation signal'' that typically contains informatio ...

s; and dual

monoamine releasing agent A monoamine releasing agent (MRA), or simply monoamine releaser, is a drug that induces the release of a monoamine neurotransmitter from the presynaptic neuron into the synapse, leading to an increase in the extracellular concentrations of the ...

s and

serotonin receptor agonist A serotonin receptor agonist is an agonist of one or more serotonin receptors. They activate serotonin receptors in a manner similar to that of serotonin (5-hydroxytryptamine; 5-HT), a neurotransmitter and hormone and the endogenous ligand ...

s like isoAMT (PAL-569).

JRT JRT may refer to: Broadcasters * Yugoslav Radio Television (1956–1992) * Shikoku Broadcasting, Japan (founded 1952) Languages * JRT (programming language), a 1980s implementation of Pascal * Chakato language, spoken in Nigeria (ISO 639-3:k ...

is the isotryptamine analogue of

LSD Lysergic acid diethylamide (LSD), also known colloquially as acid, is a potent psychedelic drug. Effects typically include intensified thoughts, emotions, and sensory perception. At sufficiently high dosages LSD manifests primarily mental, vi ...

and may be considered a cyclized isotryptamine.

References

Serotonin receptor modulators {{Organic-compound-stub