Isoquercetin, isoquercitrin or isotrifoliin is a

flavonoid Flavonoids (or bioflavonoids; from the Latin word ''flavus'', meaning yellow, their color in nature) are a class of polyphenolic secondary metabolites found in plants, and thus commonly consumed in the diets of humans. Chemically, flavonoids ...

, a type of chemical compound. It is the 3-''O''- glucoside of

quercetin Quercetin is a plant flavonol from the flavonoid group of polyphenols. It is found in many fruits, vegetables, leaves, seeds, and grains; capers, red onions, and kale are common foods containing appreciable amounts of it. It has a bitter flavor ...

. Isoquercitrin can be isolated from various plant species including ''

Mangifera indica ''Mangifera indica'', commonly known as mango, is a species of flowering plant in the family Anacardiaceae. It is a large fruit tree, capable of growing to a height of . There are two distinct genetic populations in modern mangoesthe "Indian type ...

'' (

mango A mango is an edible stone fruit produced by the tropical tree '' Mangifera indica''. It is believed to have originated in the region between northwestern Myanmar, Bangladesh, and northeastern India. ''M. indica'' has been cultivated in Sout ...

) and '' Rheum nobile'' (the Noble rhubarb). It is also present in the leaves of ''

Annona squamosa ''Annona squamosa'' is a small, well-branched tree or shrub from the family Annonaceae that bears edible fruits called sugar-apples or . It tolerates a tropical lowland climate better than its relatives ''Annona reticulata'' and ''Annona cheri ...

'', ''

Camellia sinensis ''Camellia sinensis'' is a species of evergreen shrub or small tree in the flowering plant family Theaceae. Its leaves and leaf buds are used to produce the popular beverage, tea. Common names include tea plant, tea shrub, and tea tree (not ...

'' ( tea). and ''

Vestia foetida ''Vestia'' is a monotypic genusLas Penas, M. L., et al. (2006)Karyotypes of some species of ''Cestrum'', ''Sessea'', and ''Vestia'' (tribe Cestreae, Solanaceae).''Caryologia'' 59(2) 131-37. of flowering plants in the family Solanaceae containi ...

Spectral data

The lambda-max for isoquercetin is 254.8 and 352.6 nm.

Potential clinical uses

Isoquercetin is presently being investigated for prevention of thromboembolism in selected cancer patients and as an anti-

fatigue Fatigue describes a state of tiredness that does not resolve with rest or sleep. In general usage, fatigue is synonymous with extreme tiredness or exhaustion that normally follows prolonged physical or mental activity. When it does not resolve ...

agent in kidney cancer patients treated with sunitinib. There is a single case report of its use in the successful treatment of prurigo nodularis, a difficult to treat pruritic eruption of the skin. However it belongs to the PAINS (Pan-assay interference compounds) categories of chemicals.

Spectral data

Potential clinical uses

References

See also