Isometamidium chloride is a

triazene Triazene is an unsaturated inorganic compound having the chemical formula N3 H3. It has one double bond and is the second-simplest member of the azene class of hydronitrogen compounds, after diimide. Triazenes are a class of organic compound ...

trypanocidal agent A trypanocidal agent is an antiprotozoal agent that acts upon trypanosome parasites. Examples include: * Aminoquinuride * benzonidazole * blasticidin S * DAPI * diminazene * diminazene aceturate * eflornithine * ethidium * isometamidium chlor ...

used in veterinary medicine. It consists of a single

ethidium bromide Ethidium bromide (or homidium bromide, chloride salt homidium chloride) is an intercalating agent commonly used as a fluorescent tag (nucleic acid stain) in molecular biology laboratories for techniques such as agarose gel electrophoresis. It ...

like subunit linked to a fragment of the

diminazene Diminazene (INN; also known as diminazen) is an anti-infective medication for animals that is sold under a variety of brand names. It is effective against certain protozoa such as ''Babesia'', ''Trypanosoma'', and '' Cytauxzoon''. The drug may al ...

molecule.

Resistance

The

Gibe River The Gibe River (also Great Gibe River) is by far the largest tributary of the Omo River in southwestern Ethiopia and flows generally south-southeast. The confluence of the Gibe River with the smaller Wabe River forms the Omo River. The whole dr ...

Valley in southwest

Ethiopia Ethiopia, officially the Federal Democratic Republic of Ethiopia, is a landlocked country located in the Horn of Africa region of East Africa. It shares borders with Eritrea to the north, Djibouti to the northeast, Somalia to the east, Ken ...

showed universal resistance between July 1989 and February 1993. This likely indicates a permanent loss of function in this area against the tested target, '' T. congolense'' isolated from

Boran cattle Boran cattle are a popular Zebu beef breed in eastern Africa. Through DNA sampling, Hanotte et al. have analyzed the genetic make-up of the Boran and it consists of the following genetic proportions—64% ''Bos indicus'', 24% European ''Bos tau ...

References

Amidines Antiparasitic agents Quaternary ammonium compounds Triazenes {{antiinfective-drug-stub