An Isograft is a
graft of tissue between two individuals who are genetically identical (i.e.
monozygotic twins).
Transplant rejection between two such individuals virtually never occurs, making isografts particularly relevant to organ transplantations; patients with organs from their identical twins are incredibly likely to receive the organs favorably and survive. Monozygotic twins have the same
major histocompatibility complex
The major histocompatibility complex (MHC) is a large Locus (genetics), locus on vertebrate DNA containing a set of closely linked polymorphic genes that code for Cell (biology), cell surface proteins essential for the adaptive immune system. The ...
, leading to the low instances of tissue rejection by the
adaptive immune system
The adaptive immune system (AIS), also known as the acquired immune system, or specific immune system is a subsystem of the immune system that is composed of specialized cells, organs, and processes that eliminate pathogens specifically. The ac ...
. Furthermore, there is virtually no incidence of
graft-versus-host disease
Graft-versus-host disease (GvHD) is a syndrome, characterized by inflammation in different organs. GvHD is commonly associated with bone marrow transplants and stem cell transplants.
White blood cells of the donor's immune system which rema ...
.
In 1993 a research article demonstrated that islet isografts were being transplanted into young diabetic mice
TZ induced diabetic NOD miceand the mice survived at least about 22 days post transplantation.
Effect of STZ Administration on Islet Isograft and Allograft Survival in NOD Mice
''Diabetes'' Vol 42, February 1993. Retrieved 25 June 2014.
References
Immunology
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