Isoorientin (or homoorientin) is a
flavone
Flavone is an organic compound with the formula . A white solid, flavone is a derivative of chromone with a phenyl (Ph) substituent adjacent to the ether group. The compound is of little direct practical importance, but susbstituted derivatives, t ...
, a chemical flavonoid-like compound. It is the luteolin-6-C-glucoside.
Bioassay-directed fractionation techniques led to isolation of isoorientin as the main
hypoglycaemic component in ''
Gentiana olivieri''. Studies also showed that isoorientin is a potential
neuroprotective
Neuroprotection refers to the relative preservation of neuronal structure and/or function. In the case of an ongoing insult (a neurodegenerative insult) the relative preservation of neuronal integrity implies a reduction in the rate of neuronal los ...
compound against
Alzheimer's disease.
Natural occurrences
Isoorientin can be isolated from the
passion flower
''Passiflora'', known also as the passion flowers or passion vines, is a genus of about 550 species of flowering plants, the type genus of the family Passifloraceae.
They are mostly tendril-bearing vines, with some being shrubs or trees. The ...
, ''
Vitex negundo
''Vitex negundo'', commonly known as the Chinese chaste tree, five-leaved chaste tree, or horseshoe vitex, or nisinda is a large aromatic shrub with quadrangular, densely whitish, tomentose branchlets. It is widely used in folk medicine, ...
'', ''
Terminalia myriocarpa
''Terminalia myriocarpa'', the East Indian almond, is a tree species in the genus '' Terminalia'' found in Southeast Asia.
Ecology
The larvae of the moth '' Acrocercops terminaliae'' feed on ''T. myriocarpa''.
Chemistry
The phenolic compounds ...
'', the
Açaí palm
The açaí palm (, , from Nheengatu ''asai''), ''Euterpe oleracea,'' is a species of palm tree ( Arecaceae) cultivated for its fruit (açaí berries, or simply açaí), hearts of palm (a vegetable), leaves, and trunk wood. Global demand for th ...
and ''
Swertia japonica
''Swertia'' is a genus in the gentian family containing plants sometimes referred to as the felworts. Some species bear very showy purple and blue flowers. Many members of this genus have medicinal and cultural purposes.
Plants of genus ''Fraser ...
''.
Metabolism
*
Isoorientin 3'-O-methyltransferase
In enzymology, an isoorientin 3'-O-methyltransferase () is an enzyme that catalyzes
Catalysis () is the process of increasing the rate of a chemical reaction by adding a substance known as a catalyst (). Catalysts are not consumed in the r ...
See also
*
Orientin
Orientin is a flavone, a chemical flavonoid-like compound. It is the 8-C glucoside of luteolin.
Natural occurrences
Orientin is found in ''Adonis vernalis'', in '' Anadenanthera colubrina'' and '' Anadenanthera peregrina'', and in the '' Phyllo ...
, the 8-C
glucoside of
luteolin
Luteolin is a flavone, a type of flavonoid, with a yellow crystalline appearance.
Luteolin is the principal yellow dye compound that is obtained from the plant ''Reseda luteola'', which has been used as a source of the dye since at least the firs ...
.
References
Flavone glucosides
C-glycoside natural phenols
{{aromatic-stub