''Isaria sinclairii'' is a species of

entomopathogenic fungus Entomopathogenic fungi are parasitic unicellular or multicellular microorganisms belonging to the kingdom of Fungi, that can infect and seriously disable or kill insects. Pathogenicity for insects is widely distributed in the kingdom of fungi and ...

mostly infecting the underground nymphs of

cicada The cicadas () are a superfamily, the Cicadoidea, of insects in the order Hemiptera (true bugs). They are in the suborder Auchenorrhyncha, along with smaller jumping bugs such as leafhoppers and froghoppers. The superfamily is divided into two ...

s. It produces myriocin, from which the synthetic drug

fingolimod Fingolimod, sold under the brand name Gilenya, is an immunomodulating medication, used for the treatment of multiple sclerosis. Fingolimod is a sphingosine-1-phosphate receptor modulator, which sequesters lymphocytes in lymph nodes, preventin ...

, a treatment for

multiple sclerosis Multiple sclerosis (MS) is an autoimmune disease resulting in damage to myelinthe insulating covers of nerve cellsin the brain and spinal cord. As a demyelinating disease, MS disrupts the nervous system's ability to Action potential, transmit ...

, was developed.

Taxonomy

''Isaria sinclairii'' is the name of the

anamorph In mycology, the terms teleomorph, anamorph, and holomorph apply to portions of the life cycles of fungi in the phyla Ascomycota and Basidiomycota: *Teleomorph: the sexual reproductive stage (morph), typically a fruiting body. *Anamorph: an ase ...

; the teleomorph is ''Cordyceps sinclairii'', Cordycipitaceae. The species was first described in 1855 by

Miles Joseph Berkeley Miles Joseph Berkeley (1 April 1803 – 30 July 1889) was an English cryptogamist and clergyman, and one of the founders of the science of plant pathology. Life Berkeley was born at Biggin Hall, Benefield, Northamptonshire, and educated at ...

from specimens collected in the garden of Archdeacon William Williams at

Tūranga Tūranga is the public library located in Central Christchurch, New Zealand. It opened on 12 October 2018 and replaced the nearby Christchurch Central Library that was closed on the day of the 2011 Christchurch earthquake. Location and prior bu ...

Poverty Bay Poverty Bay (Māori language, Māori: ''Tūranganui-a-Kiwa''), officially named Tūranganui-a-Kiwa / Poverty Bay, is the largest of several small bays on the east coast of New Zealand's North Island to the north of Hawke Bay. It stretches for ...

. It was moved to the genus '' Isaria'' in 1923 by

Curtis Gates Lloyd Curtis Gates Lloyd (July 17, 1859 – November 11, 1926) was an American mycologist known for both his research on the gasteroid and polypore fungi, as well as his controversial views on naming conventions in taxonomy. He had a herbarium with ab ...

Ecology

''Isaria sinclairii'' is a fungus which attacks insects, including

larva A larva (; : larvae ) is a distinct juvenile form many animals undergo before metamorphosis into their next life stage. Animals with indirect development such as insects, some arachnids, amphibians, or cnidarians typically have a larval phase ...

e. The larvae typically die just beneath the soil surface, and the fungus produces white tufts which grow up from the soil and release powdery white

spore In biology, a spore is a unit of sexual reproduction, sexual (in fungi) or asexual reproduction that may be adapted for biological dispersal, dispersal and for survival, often for extended periods of time, in unfavourable conditions. Spores fo ...

s. ''I. sinclairii'' is found from Asia (particularly China, Japan, and Korea) through to New Zealand. In New Zealand it attacks cicadas of the

genera Genus (; : genera ) is a taxonomic rank above species and below family as used in the biological classification of living and fossil organisms as well as viruses. In binomial nomenclature, the genus name forms the first part of the binomial s ...

'' Amphipsalta'' and '' Melampsalta.'' In the lab it can be cultured on the bodies of

silkworms ''Bombyx mori'', commonly known as the domestic silk moth, is a moth species belonging to the family Bombycidae. It is the closest relative of '' Bombyx mandarina'', the wild silk moth. Silkworms are the larvae of silk moths. The silkworm is of ...

Uses

''Isaria sinclairii'' and similar vegetable caterpillar species such as ''

Ophiocordyceps sinensis ''Ophiocordyceps sinensis'' (synonym (taxonomy), synonym ''Cordyceps sinensis''), known colloquially as caterpillar fungus, is an entomopathogenic fungus (a fungus that grows on insects) in the family Ophiocordycipitaceae. It is mainly found ...

'' have been used in

traditional Tibetan medicine Traditional Tibetan medicine or Sowa Rigpa is the Tibetan medical system developed in the 8th century under King Trisong Detsen that incorporated the best international medical practices of that time.Claude Arpi, ''Glimpses on the Tibet History' ...

and in

traditional Chinese medicine Traditional Chinese medicine (TCM) is an alternative medicine, alternative medical practice drawn from traditional medicine in China. A large share of its claims are pseudoscientific, with the majority of treatments having no robust evidence ...

as tonics believed to impart

eternal youth Eternal youth is the concept of human physical immortality free of ageing. The youth referred to is usually meant to be in contrast to the depredations of aging, rather than a specific age of the human lifespan. Eternal youth is common in mytho ...

. A

sphingolipid Sphingolipids are a class of lipids containing a backbone of sphingoid bases, which are a set of aliphatic amino alcohols that includes sphingosine. They were discovered in brain extracts in the 1870s and were named after the mythological sp ...

derivative produced by ''I. sinclairii'', myriocin, was discovered to have powerful immunosuppressive properties, a function of the way the fungus attacks living insects. Because myriocin is too toxic to use in humans, a synthetic derivative was developed in 1992, named FTY720 or

. Under its trade name Gilenya, fingolimod was approved by the

FDA The United States Food and Drug Administration (FDA or US FDA) is a federal agency of the Department of Health and Human Services. The FDA is responsible for protecting and promoting public health through the control and supervision of food ...

in 2010 as the first oral drug for treating the autoimmune disease

. Fingolimod shows promise as a cancer medication, and has been tested as a possible treatment for obesity.

References

External links

ARS Collection of Entomopathogenic Fungal Cultures
*''Isaria sinclairii'' discussed on

RNZ Radio New Zealand (), commonly known as RNZ or Radio NZ, is a New Zealand public service broadcaster and Crown entity. Established under the Radio New Zealand Act 1995, it operates news and current affairs station, RNZ National, and a classica ...

Critter of the Week ''Critter of the Week'' is a weekly RNZ National programme about endangered and neglected native plants and animals of New Zealand. Beginning in 2015, ''Critter of the Week'' is an approximately 15-minute discussion between Nicola Toki (origi ...

''
25 January 2019
{{Taxonbar, from=Q6078965 Clavicipitaceae Fungi described in 1855 Taxa named by Miles Joseph Berkeley Fungus species