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Isamoltane (CGP-361A) is a
drug A drug is any chemical substance that causes a change in an organism's physiology or psychology when consumed. Drugs are typically distinguished from food and substances that provide nutritional support. Consumption of drugs can be via inhal ...
used in
scientific research The scientific method is an empirical method for acquiring knowledge that has characterized the development of science since at least the 17th century (with notable practitioners in previous centuries; see the article history of scientific ...
. It acts as an antagonist at the
β-adrenergic The adrenergic receptors or adrenoceptors are a class of G protein-coupled receptors that are targets of many catecholamines like norepinephrine (noradrenaline) and epinephrine (adrenaline) produced by the body, but also many medications like beta ...
, 5-HT1A, and 5-HT1B receptors. It has about five times the potency for the 5-HT1B receptor (21 nmol/L) over the 5-HT1A receptor (112 nmol/L). It has
anxiolytic An anxiolytic (; also antipanic or antianxiety agent) is a medication or other intervention that reduces anxiety. This effect is in contrast to anxiogenic agents which increase anxiety. Anxiolytic medications are used for the treatment of anxie ...
effects in rodents.


References

{{Serotonin receptor modulators 5-HT1A antagonists 5-HT1B antagonists Secondary alcohols Beta blockers Phenol ethers Pyrroles Isopropyl compounds Amines