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Irwin Allan Rose (July 16, 1926 – June 2, 2015) was an American
biologist A biologist is a scientist who conducts research in biology. Biologists are interested in studying life on Earth, whether it is an individual cell, a multicellular organism, or a community of interacting populations. They usually specialize in ...
. Along with Aaron Ciechanover and Avram Hershko, he was awarded the 2004 Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation.


Education and early life

Rose was born in Brooklyn, New York, into a secular Jewish family, the son of Ella (Greenwald) and Harry Royze, who owned a flooring store. including the Nobel Lecture on December 8, 2004 ''Ubiquitin at Fox Chase'' Rose attended Washington State University for one year prior to serving in the Navy during World War II. Upon returning from the war he received his Bachelor of Science degree in 1948 and his
PhD PHD or PhD may refer to: * Doctor of Philosophy (PhD), an academic qualification Entertainment * '' PhD: Phantasy Degree'', a Korean comic series * ''Piled Higher and Deeper'', a web comic * Ph.D. (band), a 1980s British group ** Ph.D. (Ph.D. albu ...
in biochemistry in 1952, both from the University of Chicago. He did his post-doctoral studies at NYU.


Career and research

Rose served on the faculty of Yale School of Medicine's department of biochemistry from 1954 to 1963. He then joined the Fox Chase Cancer Center in 1963 and stayed there until he retired in 1995. He joined University of Pennsylvania during the 1970s and served as a Professor of Physical Biochemistry. He was a distinguished professor-in-residence in the Department of Physiology and Biophysics at the University of California, Irvine School of Medicine at the time his Nobel Prize was announced in 2004. Irwin (Ernie) trained several postdoctoral research fellows while at the Fox Chase Cancer Center in Philadelphia. These included Art Haas, the first to see Ubiquitin chains, Keith Wilkinson, the one to first identify APF-1 as Ubiquitin, and Cecile Pickart, a world class enzymologist in many parts of the Ub system.


Awards and honors

Rose was awarded the Nobel prize in 2004.


Personal life

Rose was married to Zelda Budenstein and had four children. He died on June 2, 2015 at Deerfield, Massachusetts. His wife died in 2016.


References


External links

* including the Nobel Lecture on December 8, 2004 ''Ubiquitin at Fox Chase'' {{DEFAULTSORT:Rose, Irwin 1926 births 2015 deaths American biologists American Nobel laureates Jewish American scientists Members of the United States National Academy of Sciences Nobel laureates in Chemistry People from Spokane, Washington University of California, Irvine faculty University of Chicago alumni United States Navy personnel of World War II Fox Chase Cancer Center people