Irene Miguel-Aliaga is a Spanish-British physiologist who is Professor of Genetics and Physiology at

Imperial College London Imperial College London, also known as Imperial, is a Public university, public research university in London, England. Its history began with Prince Albert of Saxe-Coburg and Gotha, Prince Albert, husband of Queen Victoria, who envisioned a Al ...

. Her research investigates the plasticity of adult organs, and why certain organs change shape in response to environmental changes. She was elected

Fellow of the Royal Society Fellowship of the Royal Society (FRS, ForMemRS and HonFRS) is an award granted by the Fellows of the Royal Society of London to individuals who have made a "substantial contribution to the improvement of natural science, natural knowledge, incl ...

in 2022.

Early life and education

Miguel-Aliaga is from Spain and grew up in

Barcelona Barcelona ( ; ; ) is a city on the northeastern coast of Spain. It is the capital and largest city of the autonomous community of Catalonia, as well as the second-most populous municipality of Spain. With a population of 1.6 million within c ...

. She completed her Doctor of Philosophy degree at the

University of Oxford The University of Oxford is a collegiate university, collegiate research university in Oxford, England. There is evidence of teaching as early as 1096, making it the oldest university in the English-speaking world and the List of oldest un ...

, supervised by

Kay Davies Dame Kay Elizabeth Davies (''née'' Partridge; born 1 April 1951) is a British geneticist. She is Dr Lee's Professor of Anatomy at the University of Oxford and a Fellow of Hertford College, Oxford. She is director of the Medical Research Cou ...

on invertebrate models of human diseases.

Research and career

After her PhD, she moved to the United States for

postdoctoral research A postdoctoral fellow, postdoctoral researcher, or simply postdoc, is a person professionally conducting research after the completion of their doctoral studies (typically a PhD). Postdocs most commonly, but not always, have a temporary acade ...

, joining the laboratory of Stefan Thor at

Harvard University Harvard University is a Private university, private Ivy League research university in Cambridge, Massachusetts, United States. Founded in 1636 and named for its first benefactor, the History of the Puritans in North America, Puritan clergyma ...

. Miguel-Aliaga then moved to

Linköping University Linköping University (LiU; ) is a public university, public research university based in Linköping, Sweden. Originally established in 1969, it was granted full university status in 1975 and is one of Sweden's largest academic institutions. T ...

, where she characterised the neurons of ''

Drosophila ''Drosophila'' (), from Ancient Greek δρόσος (''drósos''), meaning "dew", and φίλος (''phílos''), meaning "loving", is a genus of fly, belonging to the family Drosophilidae, whose members are often called "small fruit flies" or p ...

''. She was awarded a

Marie Skłodowska-Curie Actions Marie Skłodowska-Curie Actions (MSCA) is a set of major research fellowships created by the European Union/European Commission to support research in the European Research Area (ERA). The Marie Skłodowska-Curie Actions are among Europe's most co ...

fellowship and joined Alex Gould at the

National Institute for Medical Research The National Institute for Medical Research (NIMR), was a medical research institute based in Mill Hill, on the outskirts of north London, England. It was funded by the Medical Research Council (MRC); In 2016, the NIMR became part of the new F ...

, where she studied the specification of gut-innervating insulin-producing neurons. In 2008, Miguel-Aliaga started her independent research career at the

University of Cambridge The University of Cambridge is a Public university, public collegiate university, collegiate research university in Cambridge, England. Founded in 1209, the University of Cambridge is the List of oldest universities in continuous operation, wo ...

. She was named a

Wellcome Trust The Wellcome Trust is a charitable foundation focused on health research based in London, United Kingdom. It was established in 1936 with legacies from the pharmaceutical magnate Henry Wellcome (founder of Burroughs Wellcome, one of the predec ...

Career Development Fellow, and eventually moved to

. At Imperial, Miguel-Aliaga serves as Professor of Genetics and Physiology. Miguel-Aliaga's research investigates the plasticity of human organs, and in particular, how fully developed adult organs are impacted by environmental changes. To understand these processes, Miguel-Aliaga makes use of the

gastrointestinal tract The gastrointestinal tract (GI tract, digestive tract, alimentary canal) is the tract or passageway of the Digestion, digestive system that leads from the mouth to the anus. The tract is the largest of the body's systems, after the cardiovascula ...

, as it allows for the study of how an organ senses signals from its internal and external environments. To better understand the functional significance of various organs, Miguel-Aliaga compared the

intestinal epithelium The intestinal epithelium is the single cell layer that forms the luminal surface (lining) of both the small and large intestine (colon) of the gastrointestinal tract. Composed of simple columnar epithelium its main functions are absorptio ...

of males and females. She identified that different biological sexes demonstrate different brain-gut communications, particularly during production and tumour formation. As part of this work, her group identified the communication pathways that exist between the gastrointestinal tract and other organs. She has continued to use the model organism ''

'', as it shares over 60% of its genes with humans.

Awards and honours

* 2012

European Molecular Biology Organization The European Molecular Biology Organization (EMBO) is a professional, non-profit organization of more than 2,100 life scientists. Its goal is to promote research in life science and enable international exchange between scientists. It co-funds cour ...

young investigator * 2015 ''

Journal of Cell Science The ''Journal of Cell Science'' (formerly the ''Quarterly Journal of Microscopical Science'') is a peer-reviewed scientific journal in the field of cell biology. The journal is published by The Company of Biologists. The journal is partnered with P ...

'' One to Watch * 2017 Elected a member of the

(EMBO) * 2018

European Research Council The European Research Council (ERC) is a public body for funding of scientific and technological research conducted within the European Union (EU). Established by the European Commission in 2007, the ERC is composed of an independent Scientific ...

advanced grant * 2018 Suffrage Science Women in Science Award * 2019 Elected a

Fellow A fellow is a title and form of address for distinguished, learned, or skilled individuals in academia, medicine, research, and industry. The exact meaning of the term differs in each field. In learned society, learned or professional society, p ...

the

Academy of Medical Sciences The Academy of Medical Sciences is an organisation established in the UK in 1998. It is one of the four UK National Academy, National Academies, the others being the British Academy, the Royal Academy of Engineering and the Royal Society. Its ...

(FMedSci) * 2022 Elected a Fellow of the

Royal Society The Royal Society, formally The Royal Society of London for Improving Natural Knowledge, is a learned society and the United Kingdom's national academy of sciences. The society fulfils a number of roles: promoting science and its benefits, re ...

(FRS) * 2022

Mary Lyon Mary Mason Lyon (; February 28, 1797 – March 5, 1849) was an American pioneer in women's education. She established the Wheaton Female Seminary in Norton, Massachusetts, (now Wheaton College) in 1834. She then established Mount Holyoke Fem ...

Medal

Selected publications

Her publications include: * ''Enteric neurons and systemic signals couple nutritional and reproductive status with intestinal homeostasis'' *''The digestive tract of Drosophila melanogaster''

References

{{DEFAULTSORT:Miguel-Aliaga, Irene Living people Spanish emigrants to the United Kingdom Alumni of the University of Oxford Academics of Imperial College London Physiologists Year of birth missing (living people) Fellows of the Royal Society Female fellows of the Royal Society