An inverse vaccine, or reverse vaccine, is a hypothetical approach to the use of

vaccine A vaccine is a biological Dosage form, preparation that provides active acquired immunity to a particular infectious disease, infectious or cancer, malignant disease. The safety and effectiveness of vaccines has been widely studied and verifi ...

s that trains the immune system to not respond to certain substances. Under

laboratory A laboratory (; ; colloquially lab) is a facility that provides controlled conditions in which scientific or technological research, experiments, and measurement may be performed. Laboratories are found in a variety of settings such as schools ...

conditions, an inverse vaccine has been shown to combat

autoimmune disease An autoimmune disease is a condition that results from an anomalous response of the adaptive immune system, wherein it mistakenly targets and attacks healthy, functioning parts of the body as if they were foreign organisms. It is estimated tha ...

s. An autoimmune disease attacks the body's own cells and substances, an inverse vaccine must counteract this. The current method of combating the effects of an autoimmune disease is to suppress the entire

immune system The immune system is a network of biological systems that protects an organism from diseases. It detects and responds to a wide variety of pathogens, from viruses to bacteria, as well as Tumor immunology, cancer cells, Parasitic worm, parasitic ...

, which means that

infection An infection is the invasion of tissue (biology), tissues by pathogens, their multiplication, and the reaction of host (biology), host tissues to the infectious agent and the toxins they produce. An infectious disease, also known as a transmis ...

s cannot be fought.

Approaches

As of 2010, human trials were underway using naked DNA that encoded specific antigens of interests, particularly for multiple sclerosis using BHT-3009, and type 1 diabetes mellitus.

Possible applications

Possible applications of inverse vaccines include: *

Multiple Sclerosis Multiple sclerosis (MS) is an autoimmune disease resulting in damage to myelinthe insulating covers of nerve cellsin the brain and spinal cord. As a demyelinating disease, MS disrupts the nervous system's ability to Action potential, transmit ...

(MS) *

Type 1 diabetes Type 1 diabetes (T1D), formerly known as juvenile diabetes, is an autoimmune disease that occurs when the body's immune system destroys pancreatic cells (beta cells). In healthy persons, beta cells produce insulin. Insulin is a hormone require ...

Psoriasis Psoriasis is a long-lasting, noncontagious autoimmune disease characterized by patches of abnormal skin. These areas are red, pink, or purple, dry, itchy, and scaly. Psoriasis varies in severity from small localized patches to complete b ...

Coeliac disease Coeliac disease (British English) or celiac disease (American English) is a long-term autoimmune disorder, primarily affecting the small intestine. Patients develop intolerance to gluten, which is present in foods such as wheat, rye, spelt ...

* Allergic

asthma Asthma is a common long-term inflammatory disease of the airways of the lungs. It is characterized by variable and recurring symptoms, reversible airflow obstruction, and easily triggered bronchospasms. Symptoms include episodes of wh ...

* Food allergies * Chronic inflammatory diseases, such as

Crohn's disease Crohn's disease is a type of inflammatory bowel disease (IBD) that may affect any segment of the gastrointestinal tract. Symptoms often include abdominal pain, diarrhea, fever, abdominal distension, and weight loss. Complications outside of the ...

* Preventing an immune response after an organ transplant * Rheumatoid arthritis As of 2024, a study is underway into the safety of an inverse vaccine against multiple sclerosis, with a small group of patients and volunteers; for an inverse vaccine against celiac disease, a safety and efficacy study is underway in a limited group of subjects.

References

{{ Reflist , refs = {{ Cite web , url = https://pme.uchicago.edu/news/inverse-vaccine-shows-potential-treat-multiple-sclerosis-and-other-autoimmune-diseases , title = "Inverse vaccine" shows potential to treat multiple sclerosis and other autoimmune diseases , access-date = 2023-12-04 , author = Sarah C.P. Williams , date = 2023-09-11 , website = The University of Chicago , archive-url = https://web.archive.org/web/20231203021937/https://pme.uchicago.edu/news/inverse-vaccine-shows-potential-treat-multiple-sclerosis-and-other-autoimmune-diseases , archive-date = 2023-12-03 , url-status = live , quote = A new type of vaccine developed by researchers at the University of Chicago’s Pritzker School of Molecular Engineering (PME) has shown in the lab setting that it can completely reverse autoimmune diseases like multiple sclerosis and type 1 diabetes — all without shutting down the rest of the immune system. {{ Cite web , url = https://www.civilsdaily.com/news/autoimmune-diseases-and-inverse-vaccines/ , title = Autoimmune Diseases and the Promise of Inverse Vaccines , access-date = 2023-12-04 , date = 2023-10-02 , website = CivilsDaily , archive-url = https://web.archive.org/web/20231010095329/https://www.civilsdaily.com/news/autoimmune-diseases-and-inverse-vaccines/ , archive-date = 2023-10-10 , url-status = live , quote = In the quest to combat autoimmune diseases, scientists are exploring a groundbreaking approach: inverse vaccines. While still in the developmental stage and yet to be tested on humans, this novel concept holds the potential to revolutionize the treatment of autoimmune diseases. {{ Cite web , url = https://anokion.com/pipeline/ , title = Pipeline – Anokion , access-date = 2024-02-18 , website = Anokion SA , archive-url = https://archive.today/20240218012020/https://anokion.com/pipeline/ , archive-date = 2024-02-18 , url-status = live , quote = {{ Cite web , url = https://clinicaltrials.gov/study/NCT05574010?term=KAN-101 , title = A Study of Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of KAN-101 in Celiac Disease (ACeD-it) , access-date = 2024-02-18 , date = 2024-01-16 , website = National Center for Biotechnology Information , archive-url = https://web.archive.org/web/20240218012819/https://clinicaltrials.gov/study/NCT05574010?term=KAN-101 , archive-date = 2024-02-18 , url-status = live , quote = This study is to evaluate the Pharmacodynamic (PD), safety, tolerability, Pharmacokinetic (PK), and plasma biomarker response of KAN-101 in participants with Celiac Disease (CeD). {{ Cite web , url = https://foodallergyfund.org/research-1/2021/2/15/inverse-food-allergy-vaccines-through-targeted-antigen-delivery , title = Inverse Food Allergy Vaccines Through Targeted Antigen Delivery — Food Allergy Fund , access-date = 2023-12-04 , author = Dr. Jeffrey A. Hubbell , author2 = Dr. Cathryn R. Nagler , date = 2023-07-10 , website = Food Allergy Fund , archive-url = https://web.archive.org/web/20231204190212/https://foodallergyfund.org/research-1/2021/2/15/inverse-food-allergy-vaccines-through-targeted-antigen-delivery , archive-date = 2023-12-04 , url-status = live , quote = Researchers know that something called “food antigens” create tolerance for specific food proteins. Now researchers want to create an inverse vaccine that puts those particular food antigens to work inside of food allergic individuals so they can tolerate their allergens.

External links

What is an inverse vaccine and how can it reverse autoimmune disorders?
(Video)
Inverse vaccination, the opposite of Jenner’s concept, for therapy of autoimmunity
Vaccines Autoimmune diseases Experimental drugs Immunotherapy

Approaches

Possible applications

See also

References

External links