Intussusceptive angiogenesis also known as splitting angiogenesis, is a type of angiogenesis, the process whereby a new

blood vessel Blood vessels are the structures of the circulatory system that transport blood throughout the human body. These vessels transport blood cells, nutrients, and oxygen to the tissues of the body. They also take waste and carbon dioxide away from ...

is created. By intussusception a new blood vessel is created by splitting of an existing blood vessel in two. Intussusception occurs in normal development as well as in pathologic conditions involving wound healing, tissue regeneration, inflammation as colitis or myocarditis, lung fibrosis, and tumors amongst others. Intussusception was first observed in neonatal rats. In this type of vessel formation, the

capillary A capillary is a small blood vessel from 5 to 10 micrometres (μm) in diameter. Capillaries are composed of only the tunica intima, consisting of a thin wall of simple squamous endothelial cells. They are the smallest blood vessels in the body: ...

wall extends into the lumen to split a single vessel in two. There are four phases of intussusceptive angiogenesis. First, the two opposing capillary walls establish a zone of contact. Second, the

endothelial cell The endothelium is a single layer of squamous endothelial cells that line the interior surface of blood vessels and lymphatic vessels. The endothelium forms an interface between circulating blood or lymph in the lumen and the rest of the ves ...

junctions are reorganized and the vessel bilayer is perforated to allow growth factors and cells to penetrate into the lumen. Third, a core is formed between the two new vessels at the zone of contact that is filled with

pericyte Pericytes (previously known as Rouget cells) are multi-functional mural cells of the microcirculation that wrap around the endothelial cells that line the capillaries throughout the body. Pericytes are embedded in the basement membrane of blood ...

s and myofibroblasts. These cells begin laying collagen fibers into the core to provide an

extracellular matrix In biology, the extracellular matrix (ECM), also called intercellular matrix, is a three-dimensional network consisting of extracellular macromolecules and minerals, such as collagen, enzymes, glycoproteins and hydroxyapatite that provide struc ...

for growth of the vessel lumen. Finally, the core is fleshed out with no alterations to the basic structure. Intussusception is important because it is a reorganization of existing cells. It allows a vast increase in the number of

capillaries A capillary is a small blood vessel from 5 to 10 micrometres (μm) in diameter. Capillaries are composed of only the tunica intima, consisting of a thin wall of simple squamous endothelial cells. They are the smallest blood vessels in the body: ...

without a corresponding increase in the number of

s. This is especially important in embryonic development as there are not enough resources to create a rich microvasculature with new cells every time a new vessel develops.

Research

In a small study comparing the lungs of patients who had died from

COVID-19 Coronavirus disease 2019 (COVID-19) is a contagious disease caused by a virus, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The first known case was identified in Wuhan, China, in December 2019. The disease quickl ...

to those that had died from influenza A pneumonia (H1N1) to uninfected controls during autopsy; there was a significantly greater density of intussusceptive angiogenic features in the lungs of patients who had died from Covid-19 as compared to influenza A and the control group. The degree of intussusceptive angiogenic features in the lungs from the Covid-19 patients were also found to be greater as the length of hospitalization increased (which was not seen in the influenza or control groups). This suggests that increased or enhanced intussusceptive angiogenesis is seen in Covid-19 and may play a role in pathogenesis.

References

*''Mentzer SJ, Konerding MA. Intussusceptive angiogenesis: Expansion and remodeling of microvascular networks. Angiogenesis 2014;17:499-509. *''Vascular remodeling by intussusceptive angiogenesis'', Djonov V, Baum O, Burri PH., Cell and Tissue Research, 2003 Oct;314(1):107-17 *''Ackermann M, Verleden SE, Kuehnel M, et al. Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19 ublished online ahead of print, 2020 May 21 N Engl J Med. 2020;10.1056/NEJMoa2015432. doi:10.1056/NEJMoa2015432 *
www.intussusception.org
' Angiology {{circulatory-stub