An intracameral injection is usually of an
antibiotic
An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting pathogenic bacteria, bacterial infections, and antibiotic medications are widely used in the therapy ...
into the
anterior chamber of the eyeball to prevent
endophthalmitis
Endophthalmitis, or endophthalmia, is inflammation of the interior cavity of the eye, usually caused by an infection. It is a possible complication of all intraocular surgeries, particularly cataract surgery, and can result in loss of vision or l ...
caused by an infection of the eye that can occur after
cataract surgery
Cataract surgery, also called lens replacement surgery, is the removal of the natural lens (anatomy), lens of the human eye, eye that has developed a cataract, an opaque or cloudy area. The eye's natural lens is usually replaced with an artific ...
. The
Food and Drug Administration (FDA) has not approved antibiotics for this use and it is considered 'off-label'. Concerns about this procedure contributing to increasing numbers of
antibiotic resistant bacteria
A list of antibiotic resistant bacteria is provided below. These bacteria have shown antibiotic resistance (or antimicrobial resistance).
Gram positive
''Clostridioides difficile''
''Clostridioides difficile'' is a nosocomial pathogen tha ...
have been expressed.
In the UK, Aprokam cefuroxime has been approved for use in intracameral injections.
Intracameral injection of
recombinant tissue plasminogen activator (r-TPA) has been found to be effective in treating the development of
fibrin
Fibrin (also called Factor Ia) is a fibrous protein, fibrous, non-globular protein involved in the Coagulation, clotting of blood. It is formed by the action of the protease thrombin on fibrinogen, which causes it to polymerization, polymerize. ...
intraocularly after the development of endophthalmitis.
References
Eye diseases
Medical emergencies
Ophthalmic drug administration
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