Interstate 88 may refer to either of two United States Interstate highways:
*
Interstate 88 (Illinois)
Interstate 88 (I-88) is an Interstate Highway in the US state of Illinois that runs from an interchange with I-80 near Silvis and Moline to an interchange with I-290 and I-294 in Hillside, near Chicago. I-88 is long. This route is not ...
, running from East Moline to Hillside
*
Interstate 88 (New York), running from Chenango to Rotterdam
{{Road disambiguation