Interstate 680 may refer to:
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Interstate 680 (California)
Interstate 680 (I-680) is a north–south auxiliary Interstate Highway in Northern California. It curves around the eastern cities of the San Francisco Bay Area from San Jose to I-80 at Fairfield, bypassing cities along the eastern shor ...
, a connecting freeway between I-80 and I-280 in the San Francisco Bay Area, California
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Interstate 680 (Nebraska–Iowa), a bypass in Omaha, Nebraska
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Interstate 680 (Ohio), a loop through Youngstown, Ohio
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Interstate 676 in Pennsylvania and New Jersey, designated as Interstate 680 back when I-76 was I-80S
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