Interstate 105 may refer to either any of three unconnected Interstate Highways in the United States, each of which is or was related to
Interstate 5
Interstate 5 (I-5) is the main north–south Interstate Highway System, Interstate Highway on the West Coast of the United States, running largely parallel to the Pacific coast of the contiguous U.S. from Mexico to Canada. It travels thro ...
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Interstate 105 (California), a spur of Interstate 5 in Los Angeles County, California
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Interstate 105 (California 1964–1968), a former part of U.S. Route 101 in downtown Los Angeles, California
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Interstate 105 (Oregon), a spur of Interstate 5 in Eugene, Oregon
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