Interleukin-1 receptor (IL-1R) is a
cytokine receptor
Cytokine receptors are receptors that bind to cytokines.
In recent years, the cytokine receptors have come to demand the attention of more investigators than cytokines themselves, partly because of their remarkable characteristics, and partly b ...
which binds
interleukin 1
The Interleukin-1 family (IL-1 family) is a group of 11 cytokines that plays a central role in the regulation of immune and inflammatory responses to infections or sterile insults.
Discovery
Discovery of these cytokines began with studies on ...
.
Two forms of the receptor exist. The
type I Type 1 or Type I or ''variant'', may refer to:
Health
*Diabetes mellitus type 1 (also known as "Type 1 Diabetes"), insulin-dependent diabetes
* Type I female genital mutilation
* Type 1 personality
*Type I hypersensitivity (or immediate hypersensit ...
receptor is primarily responsible for transmitting the
inflammatory effects of interleukin-1 (IL-1) while
type II receptors may act as a suppressor of IL-1 activity by competing for IL-1 binding.
Also opposing the effects of IL-1 is the
IL-1 receptor antagonist (IL-1RA).
The IL-1 receptor accessory protein (
IL1RAP) is a transmembrane protein that interacts with IL-1R and is required for IL-1 signal transduction.
References
External links
*
Immunoglobulin superfamily cytokine receptors
{{membrane-protein-stub