Interferon gamma receptor 1

Interferon gamma receptor 1 (IFNGR1) also known as CD119 (Cluster of Differentiation 119), is a protein that in humans is encoded by the ''IFNGR1'' gene.

Function

The gene ''IFNGR1'' encodes IFN-γR1, which is the ligand-binding chain (alpha) of the heterodimeric gamma interferon receptor, which is found on macrophages. IFNGR2, encodes IFN-γR2, the non-ligand-binding partner of the heterodimeric receptor.

Interactions

Interferon gamma receptor 1 has been shown to interact with Interferon-gamma.

Mutations

Mutations in the ''IFNGR1'' gene can lead to extreme susceptibility to Mycobacterial infections. All known mutations and common variations in the IFNGR1 are present in the IFNGR1 mutation database.

See also

* Cluster of differentiation
* Interferon-gamma receptor

References

Further reading

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External links

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Clusters of differentiation

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