Inter-ictal spiking refers to abnormal neuronal discharges between
epileptic seizure
An epileptic seizure, informally known as a seizure, is a period of symptoms due to abnormally excessive or neural oscillation, synchronous neuronal activity in the brain. Outward effects vary from uncontrolled shaking movements involving much o ...
s. This abnormal activity can originate from one or more cranial
lobes, often travels from one lobe to another, and interferes with normal activity from the affected lobe. Patients with severe, intractable forms of
epilepsy
Epilepsy is a group of non-communicable neurological disorders characterized by recurrent epileptic seizures. Epileptic seizures can vary from brief and nearly undetectable periods to long periods of vigorous shaking due to abnormal electrical ...
can experience unremitting abnormal
brain
The brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals. It consists of nervous tissue and is typically located in the head ( cephalization), usually near organs for special ...
activity due to inter-ictal spiking.
This phenomenon has been confirmed through
telemetry
Telemetry is the in situ collection of measurements or other data at remote points and their automatic transmission to receiving equipment (telecommunication) for monitoring. The word is derived from the Greek roots ''tele'', "remote", and ' ...
by
electrocorticography
Electrocorticography (ECoG), or intracranial electroencephalography (iEEG), is a type of electrophysiological monitoring that uses electrodes placed directly on the exposed surface of the brain to record electrical activity from the cerebral co ...
in which
electrode
An electrode is an electrical conductor used to make contact with a nonmetallic part of a circuit (e.g. a semiconductor, an electrolyte, a vacuum or air). Electrodes are essential parts of batteries that can consist of a variety of materials ...
grids are positioned sub-durally and augmented by intra-cranial depth electrodes. The EEG tracings from these are correlated with external video recordings of physical responses to
epileptic
Epilepsy is a group of non-communicable neurological disorders characterized by recurrent epileptic seizures. Epileptic seizures can vary from brief and nearly undetectable periods to long periods of vigorous shaking due to abnormal electrical ...
seizures to help determine type of seizure and origin of onset.
Neurophysiology
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