Integrin alpha-1 also CD49a is an
integrin
Integrins are transmembrane receptors that help cell–cell and cell–extracellular matrix (ECM) adhesion. Upon ligand binding, integrins activate signal transduction pathways that mediate cellular signals such as regulation of the cell cycle, o ...
alpha subunit encoded in humans by the gene ''ITGA1''. It makes up half of the α1β1 integrin duplex. Though CD49a can bind a number of ligands including collagen IV, collagen I, and others.
CD49a has been implicated as a marker of tissue resident memory T cells, where it may be coexpressed with other markers CD103 and CD69. It has been shown to affect the motility of T cells.
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External links
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ITGA1Info with links in th
Cell Migration Gateway
PDBe-KBprovides an overview of all the structure information available in the PDB for Human Integrin alpha-1
Integrins
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