Imeglimin (EMD- 387008,PXL- 008,RVT-1501, brand name Twymeeg) is an oral

anti-diabetic Drugs used in diabetes treat types of diabetes mellitus by decreasing glucose levels in the blood. With the exception of insulin, most GLP-1 receptor agonists ( liraglutide, exenatide, and others), and pramlintide, all diabetes medications a ...

medication. It was approved for use in Japan in June 2021. It is an

oxidative phosphorylation Oxidative phosphorylation(UK , US : or electron transport-linked phosphorylation or terminal oxidation, is the metabolic pathway in which Cell (biology), cells use enzymes to Redox, oxidize nutrients, thereby releasing chemical energy in order ...

blocker that acts to inhibit hepatic

gluconeogenesis Gluconeogenesis (GNG) is a metabolic pathway that results in the biosynthesis of glucose from certain non-carbohydrate carbon substrates. It is a ubiquitous process, present in plants, animals, fungi, bacteria, and other microorganisms. In verte ...

, increase muscle

glucose Glucose is a sugar with the Chemical formula#Molecular formula, molecular formula , which is often abbreviated as Glc. It is overall the most abundant monosaccharide, a subcategory of carbohydrates. It is mainly made by plants and most algae d ...

uptake, and restore normal insulin secretion. It is the first approved drug of this class of anti-diabetic medication.

References

Anti-diabetic drugs Dimethylamino compounds {{gastrointestinal-drug-stub