IgSF CAMs (Immunoglobulin-like Cell Adhesion Molecules) are

cell adhesion molecule Cell adhesion molecules (CAMs) are a subset of cell surface proteins that are involved in the binding of cells with other cells or with the extracellular matrix (ECM), in a process called cell adhesion. In essence, CAMs help cells stick to each ...

s that belong to

Immunoglobulin superfamily The immunoglobulin superfamily (IgSF) is a large protein superfamily of cell surface and soluble proteins that are involved in the recognition, binding, or adhesion processes of cells. Molecules are categorized as members of this superfamily ...

. It is regarded as the most diverse superfamily of CAMs. This family is characterized by their extracellular domains containing Ig-like domains. The Ig domains are then followed by

Fibronectin type III domain The Fibronectin type III domain is an evolutionarily conserved protein domain that is widely found in animal proteins. The fibronectin protein in which this domain was first identified contains 16 copies of this domain. The domain is about 100 am ...

repeats and IgSFs are anchored to the membrane by a GPI moiety. This family is involved in both homophilic or heterophilic binding and has the ability to bind integrins or different IgSF CAMs.

Examples

Here is a list of some molecules of this family: * NCAMs Neural Cell Adhesion Molecules *

ICAM-1 ICAM-1 (Intercellular adhesion molecule, Intercellular Adhesion Molecule 1) also known as CD54 (Cluster of Differentiation 54) is a protein that in humans is encoded by the ''ICAM1'' gene. This gene encodes a cell surface glycoprotein which is ty ...

Intercellular Cell Adhesion Molecule *

VCAM-1 Vascular cell adhesion protein 1 also known as vascular cell adhesion molecule 1 (VCAM-1) or cluster of differentiation 106 (CD106) is a protein that in humans is encoded by the ''VCAM1'' gene. VCAM-1 functions as a cell adhesion molecule. Str ...

Vascular Cell Adhesion Molecule *

PECAM-1 Platelet endothelial cell adhesion molecule (PECAM-1) also known as cluster of differentiation 31 (CD31) is a protein that in humans is encoded by the ''PECAM1'' gene found on chromosome17q23.3. PECAM-1 plays a key role in removing aged neutro ...

Platelet-endothelial Cell Adhesion Molecule *

MAdCAM-1 Mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) is a protein that in humans is encoded by the ''MADCAM1'' gene. The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leuko ...

Mucosal Vascular Addressin Cell Adhesion Molecule *

L1 family The L1 family is a family of cell adhesion molecules that includes four different L1-like proteins. They are members of the immunoglobulin superfamily ( IgSF CAM). The members of the L1-family in humans are called L1 or L1cam, CHL1 (close homo ...

including

L1 (protein) L1, also known as L1CAM, is a transmembrane protein member of the L1 protein family, encoded by the ''L1CAM'' gene. This protein, of 200 to 220 kDa, is a neuronal cell adhesion molecule with a strong implication in cell migration, adhesion, neu ...

, CHL1, Neurofascin and

NrCAM Neuronal cell adhesion molecule is a protein that in humans is encoded by the ''NRCAM'' gene. Cell adhesion molecules Cell adhesion molecules (CAMs) are a subset of cell surface proteins that are involved in the binding of cells with other ce ...

* SIGLEC family including

Myelin-associated glycoprotein Myelin-associated glycoprotein (MAG), or Siglec-4 is a type 1 transmembrane protein, a glycoprotein localized in periaxonal Schwann cell and oligodendrocyte membranes, where it plays a role in glial-axonal interactions. MAG is a member of the SI ...

(MAG, SIGLEC-4),

CD22 CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule tha ...

and CD83 *CTX family including CTX,

Junctional adhesion molecule A junctional adhesion molecule (JAM) is a protein that is a member of the immunoglobulin superfamily, and is expressed in a variety of different tissues, such as leukocytes, platelets, and epithelial and endothelial cells. They have been shown to ...

(JAM), BT-IgSF, Coxsackie virus and adenovirus receptor (CAR), VSIG, ESAM * Nectins and related proteins, including

CADM1 Cell adhesion molecule 1 is a protein that, in humans, is encoded by the ''CADM1'' gene. Interactions Cell adhesion molecule 1 has been shown to Protein-protein interaction, interact with EPB41L3. Association studies Genome-wide association studi ...

and other Synaptic Cell Adhesion Molecules * CD2 * CD48 * HEPACAM * HEPACAM2 * DSCAM - Down syndrome cell adhesion molecule

References

{{Cell adhesion molecules Cell adhesion molecules