Ibogamine is an
anti-convulsant
Anticonvulsants (also known as antiepileptic drugs, antiseizure drugs, or anti-seizure medications (ASM)) are a diverse group of pharmacological agents used in the treatment of epileptic seizures. Anticonvulsants are also used in the treatment ...
,
anti-addictive, CNS stimulant
alkaloid
Alkaloids are a broad class of natural product, naturally occurring organic compounds that contain at least one nitrogen atom. Some synthetic compounds of similar structure may also be termed alkaloids.
Alkaloids are produced by a large varie ...
found in ''
Tabernanthe iboga'' and Crepe Jasmine (''
Tabernaemontana divaricata'').
Basic research
Basic research, also called pure research, fundamental research, basic science, or pure science, is a type of scientific research with the aim of improving scientific theories for better understanding and prediction of natural or other phenome ...
related to how
addiction
Addiction is a neuropsychological disorder characterized by a persistent and intense urge to use a drug or engage in a behavior that produces natural reward, despite substantial harm and other negative consequences. Repetitive drug use can ...
affects the brain has used this chemical.
Ibogamine persistently reduced the self-administration of cocaine and morphine in rats.
The same study found that ibogamine (40 mg/kg) and
coronaridine
Coronaridine, also known as 18-carbomethoxyibogamine, is an alkaloid found in '' Tabernanthe iboga'' and related species, including '' Tabernaemontana divaricata'' for which (under the now obsolete synonym ''Ervatamia coronaria'') it was named.
...
(40 mg/kg) did not produce "any
tremor
A tremor is an involuntary, somewhat rhythmic muscle contraction and relaxation involving neural oscillations, oscillations or twitching movements of one or more body parts. It is the most common of all involuntary movements and can affect the h ...
effects in rats that differ significantly from saline control". While the related alkaloids
ibogaine (20–40 mg/kg),
harmaline (10–40 mg/kg) and
desethylcoronaridine (10–40 mg/kg) were "obviously tremorgenic".
Chemistry
Synthesis
Ibogamine can be prepared from one-step demethoxycarbonylation process through
coronaridine
Coronaridine, also known as 18-carbomethoxyibogamine, is an alkaloid found in '' Tabernanthe iboga'' and related species, including '' Tabernaemontana divaricata'' for which (under the now obsolete synonym ''Ervatamia coronaria'') it was named.
...
.
Pharmacology
Like ibogaine, it has seems to have similar pharmacology. It has effects on
KOR,
,
nAChR and serotonin sites.
It also inhibits acetylcholinesterase and butyrylcholinesterase.
See also
*
Coronaridine
Coronaridine, also known as 18-carbomethoxyibogamine, is an alkaloid found in '' Tabernanthe iboga'' and related species, including '' Tabernaemontana divaricata'' for which (under the now obsolete synonym ''Ervatamia coronaria'') it was named.
...
*
Ibogaine
*
Ibogaline
*
Tabernanthine
*
Voacangine
*
Harmaline
References
{{Chemical classes of psychoactive drugs
Tryptamine alkaloids
Alkaloids found in Iboga
NMDA receptor antagonists
Oneirogens
Azepinoindoles